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Introduction: Apium graveolens L. has been claimed to possess therapeutic potential for central nervous system disorders. Thus, the present study aimed to evaluate its effect on scopolamin e-induced memory impairment in mice Methods: Forty-eight C57BL/6 mice were subjected to Morris water maze and object recognition test in order to determine the spatial and non-spatial memory. Additionally, the brain acetylcholinesterase (AChE) activities were also quantifi ed. Aricept was used as a positive control. Results: Oral administration of Apium graveolens L. extract (125, 250, 375 and 500 mg/kg BW for consecutive 28 days) signifi cantly decreased the escape latency time but increased the discrimination index when compared to vehicle (p<0.001) and aricept-treated groups (p<0.05). Furthermore, the AChE activities in cerebral cortex and hippocampus signifi cantly decreased in animals receiving 125, 250, 375 and 500 mg/kg BW of Apium graveolens L. extract (p<0.001) when compare to vehicle treated group and show a level similar to those observed in aricept treated group. Conclusion: These result suggested that Apium graveolens L. has benefi cial effects against scopolamine-induced amnesia by regulating cholinergic system and promoting memory enhancement via decreased activity of AChE.
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