Relationship between Lactose and Microcrystalline Cellulose as Diluents on Physical Characteristics of Banana Extract Tablet using Computer Program

Main Article Content

Sureewan Duangjit
Arunporn Itharat
Pakorn Kraisit

Abstract

Introduction: The utilization of banana in pharmaceutics has gained attention as an alternative
excipient for tablet formulation. Banana starch obtained from Musa sapientum has been used as
disintegrant in comparison study with other disintegrating agents. However, a few research works have
been done to investigate the feasibility of banana extract as binding agent in tablet formulation. To
overcome this problem, the development of banana extract tablets was performed using Design-Expert®
Software. Methods: The model formulations of banana extract tablets were processed according to
the formulation obtained from the experimental design. In this study, lactose (X1) and microcrystalline
cellulose (X2) (as formulation variables) were varied and used as diluents of banana extract tablets.
The physical characteristics i.e., weight variation (Y1), hardness (Y2), thickness (Y3), friability (Y4) and
disintegration time (Y5) of banana extract tablet (as response variables) were evaluated. Results: The
response surface predicted by Design-Expert® Software reveals an obvious relationship between the
diluents and physical characteristics. The banana extract tablets having the appropriate physical
characteristics followed the United States Pharmacopeia (USP35) criteria. Conclusion: The results
indicated that the experimental design was benefi cial for the development of pharmaceutical tablets
formulation. The fi nding provided an understanding of the relationship between formulation variables
and response variables as exhibited in the response surface.

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