Effi cacy of Triphala Formulation on Blood Lipid and Glucose: A Review of the Literature.

Main Article Content

Wiraphol Phimarn
Wanida Caichompoo
Bunlue Sungthong
Kritsanee Saramunee

Abstract

Introduction: Triphala is one of the oldest polyherbal formulation used in Thailand. Previous
study indicated could be used in blood lipid and glucose lowering. However, the effi cacy is supported
by limit evidence and seems to be contradicted. This study aimed to conduct a systematic review and
meta-analysis that investigates the effi cacy of Triphala on blood lipid and glucose. Method: Published
and unpublished papers were searched from accessible database such as Pubmed, CENTRAL,
ScienceDirect, SciSearch, and Thailis including a hand search. Study designed randomized controlled
trial in human, written in English or Thai, published before or in year 2014 were recruited. Results:
From 1,194 potentially relevant articles identifi ed, only 3 studies met our selection criteria and were
included for data analysis. Two articles used Triphala as powder and another one was not identifi ed.
The mean differences for LDL lowering was -0.29 mmol/L [95%CI (-0.42, -0.17), p<0.00001]. The mean
difference for reducing TG and FBS level were -0.37mmol/L, [95%CI (-0.90, 0.16), p=0.17] and -1.86
mmol/L [95%CI (-5.02 to 1.29), p=0.25] respectively. Conclusion: Triphala seemed to have effect on
LDL lowering when compared to placebo but was unlikely to reduce level of TG and blood glucose.
More well-designed trials are needed to determine the effi cacy of Triphala for lipid and blood glucose
lowering.

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References

Baliga MS, Meera S, Mathai B. et al. Scientifi c Validation of the Ethnomedicinal Properties of the Ayurvedic Drug Triphala: A Review. Chin J Integr Med 2012; 18(12): 946-954

Bhattacharjee R, Nekkanti S, Kumar NG, et al. Effi cacy of triphala mouth rinse (aqueous extracts) on dental plaque and gingivitis in children. J Investig Clin Dent. 2014; 5: 1–5.

Bok SH, Park SY, Park YB, Lee MK, Jeon SM, Jeong TS, Choi MS. Quercetin dihydrate and gallate supplements lower plasma and hepatic lipids and change activities of hepatic antioxidant enzymes in high cholesterol-fed rats. Int J Vitam Nutr Res 2002; 72(3):161-169.

Borgohain R. Evaluation of mechanism of anti-diabetic activity of terminalia chebulaon alloxan and adrenaline induced diabetic albino rats. Int J Pharm Bio Sci 2012; 3(3): 256 – 266.

Davidson JA, Parkin CG. Is hyperglycemia a causal factor in cardiovascular disease. Diabetes care 2009; 32 (suppl): s331-333.

Downs JR, Clearfi led M, Weis S, et al. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS: Air Force/Texas Coronary Atherosclerosis Prevention Study. JAMA. 1998; 279: 1615-22.

Jantaboon S, Poopiewkham T, Phanngam P. Phimarn W, Rinthong P. Anti-HMG CoA reductase activity of Triphala extract. IJPS 2014; suppl: 161.

Kamali SH, Khalaj AR, Hasani-Ranjbar S. et al. Effi cacy of ‘ItrifalSaghir’, a combination of three medicinal plants in the treatment of obesity; A randomized controlled trial. DARU J Pharm Sci. 2012; 20:33.

Kamali SH, Khalaj AR, Hasani-Ranjbar S, et al. A systematic review of the antioxidant, anti-diabetic, and anti-obesity effects and safety of triphala herbal formulation. J Med Plants Res 2013; 7(14): 831-844.

Naiktari RS, Gaonkar P, Gurav AN, Khiste SV. A randomized clinical trial to evaluate and compare the efficacy of triphala mouthwash with 0.2% chlorhexidine in hospitalized patients with periodontal diseases. J Periodontal Implant Sci 2014; 44: 134-140.

Punithavathi VR, Stanely M, Kumar MR, Selvakumari CJ. Protective effects of gallic acid on hepatic lipid peroxide metabolism, glycoprotein components and lipids in streptozotocin-induced type II diabetic Wistar rat. J Biochem Mol Toxicol 2011; 25(2):68-76.

Rajan SS, Antony S. Hypoglycemic effect of triphala on selected noninsulin dependent Diabetes mellitus subjects. Anc Sci Life 2008; 27(3): 45–49.

Savarikar SS. Barbhind MM, Halde UK, Kulkarni AP. Pharmaceutical and analytical evaluation of triphalaguggulkalpa tablets. J Ayurveda Integr Med. 2011; 2(1):21-5

Singh RB, Niaz MA, Rastogi V, et al. Hypolipidemic and antioxidant effects of fenugreek seeds and triphala as adjuncts to dietary therapy in patients with mild to moderate hypercholesterolemia. Perfusion 1998; 11(3):124.

Tandon S, Gupta K, Rao S, Malagi KJ. Effect of Triphala mouthwash on the caries status. Int J Ayurveda Res 2010; 1(2): 93–99.

Wichiansaen P, Punyahotra V. The effectiveness of TRIPHALA (Thai traditional medicine) on lowering blood lipid level in Hyperlipidemic subject. 2014. Available: http://www.mfu.ac.th/school/anti-aging/File_PDF/Research_PDF55/Proceeding_6.pdf.

WuT, Fu J, YangY, et al. The effects of phytosterols/stanols on blood lipid profiles: a systematic review with meta-analysis. Asia Pac J Clin Nutr 2009; 18 (2): 179-186.