Effi cacy of Triphala Formulation on Blood Lipid and Glucose: A Review of the Literature.

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Wiraphol Phimarn
Wanida Caichompoo
Bunlue Sungthong
Kritsanee Saramunee


Introduction: Triphala is one of the oldest polyherbal formulation used in Thailand. Previous
study indicated could be used in blood lipid and glucose lowering. However, the effi cacy is supported
by limit evidence and seems to be contradicted. This study aimed to conduct a systematic review and
meta-analysis that investigates the effi cacy of Triphala on blood lipid and glucose. Method: Published
and unpublished papers were searched from accessible database such as Pubmed, CENTRAL,
ScienceDirect, SciSearch, and Thailis including a hand search. Study designed randomized controlled
trial in human, written in English or Thai, published before or in year 2014 were recruited. Results:
From 1,194 potentially relevant articles identifi ed, only 3 studies met our selection criteria and were
included for data analysis. Two articles used Triphala as powder and another one was not identifi ed.
The mean differences for LDL lowering was -0.29 mmol/L [95%CI (-0.42, -0.17), p<0.00001]. The mean
difference for reducing TG and FBS level were -0.37mmol/L, [95%CI (-0.90, 0.16), p=0.17] and -1.86
mmol/L [95%CI (-5.02 to 1.29), p=0.25] respectively. Conclusion: Triphala seemed to have effect on
LDL lowering when compared to placebo but was unlikely to reduce level of TG and blood glucose.
More well-designed trials are needed to determine the effi cacy of Triphala for lipid and blood glucose


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