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Introduction: Herbal medicines are used extensively in patients with chronic pain such as
osteoarthritis (OA). There are few clinical trials to proof their effi cacy and safety. This study was
undertaken to examine the effi cacy and safety of ginger (Zingiber offi cinale Roscoe) extract in
Nanostructured Lipid Carrier (NLC) for relieving pain in knee OA patients. NLC is popular formulation
of the topical herbal medicines. Methods: Twenty patients (3 males and 17 females aged range of
50-75 years who diagnosed as OA knee. This diagnosis is based on the American College of
Rheumatology (ACR) diagnosis criteria. All participants received a treatment with ginger extract in NLC
rubbed three times a day for 4 weeks. Effi cacy was assessed by the Western Ontario and McMaster
Universities Arthritis Index (WOMAC), Knee Injury and Osteoarthritis Outcome Score (KOOS) and
patient’s global assessment (PGA). The safety of ginger extract in NLC was approved by biochemical
tests in serum and hematological parameters. The paired t-test was used to compare the average
score of effi cacy before and after treatment. Results: Ginger extract in NLC revealed its statistically
signifi cant improvement in patient’s global assessment, knee joint pain, physical function, stiffness,
symptom, sport & recreation activity and quality of life which measured by PGA, WOMAC and KOOS.
Within 4-week treatment with ginger extract in NLC, there were 2 reports of contact dermatitis adverse
event. Conclusion: A 4-week treatment with ginger extract in NLC could relieve joint pain and improve
problematic symptoms and the quality of life in knee osteoarthritis patients.
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