The frequency of KIR2DS3 in Thai population
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Abstract
Introduction: KIR2DS3, also known as NKAT7, is a cell surface receptor of natural killer (NK) cell encoded by KIR2DS3 and plays a role in immune response. KIR2DS3 is a highly polymorphic gene, and its frequency varies greatly between populations. Furthermore, KIR2DS3 has been found to be associated with many infection diseases, such as hepatitis C infection, Ebola infection, malaria and tuberculosis. This study aims to investigate the frequency of KIR2DS3 in Thai population and the distribution of this gene frequency in each region of Thailand. Methods: 100 Thai healthy volunteers unrelated individuals were randomly and proportionally (25 samples per region) selected from four regions based on their residential location according to the Department of Provincial Administration, Ministry of Interior. Their DNA samples were extracted from peripheral blood using Chelex method. Then, the DNAs were amplified and identified for KIR2DS3 gene by Polymerase Chain Reaction with Sequence-Specific Primers (PCR-SSP). Results: KIR2DS3 was found in 42 out of 100 participants (42%). In each region, KIR2DS3 was presented in 44% of the Northern (11 out of 25 samples), 72% of the Central (18 out of 25 samples), 20% of the Northeastern (5 out of 25 samples), and 32% of the Southern (8 out of 25 samples). Conclusions: The polymorphism of KIR2DS3 is found in Thai population, and its frequency varies among regional parts of Thailand; people who are located in the Northeastern region have less KIR2DS3 frequency compared with the individuals of other regions. As results, these data might be of benefits for further studies in the association of KIR2DS3 and diseases in Thai population or in the other fields such as anthropology.
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