Microneedle Techniques for DNA Transdermal Delivery
Article Sidebar
Main Article Content
Abstract
Currently, gene therapy has been the popular approach in the medical fi elds. Gene therapy relies on the use of DNA as a medicine involving the insertion of the therapeutic DNA into cells and tissue to treat a disease. Plasmid DNA based skin therapies are being tested and clinically developed for the treatment of genetic skin disorderssuch as, skin cancers, psoriasis and diabetic neuropathy. Moreover, a new approach to vaccination is currently being investigated with the concept of DNA vaccines. This new technology is interesting due to its advantages over the traditional vaccines. Skin is an optimal compartment for vaccine delivery, because of its high density of immunologic antigen-presenting cells residing both within the epidermis and dermis including Langerhans cells and dermal dendritic cells, respectively. Transdermal drug delivery offers an advantageous of drug administration and vaccine for prophylactic applications. However, the formidable barrier properties of the uppermost layer of the skin, the stratum corneum, impose signifi cant limitations for successful delivery of the therapeutic molecules particularly the macromolecules and genetic materials. Microneedle has been proposed as a strategy to breach the stratum corneum barrier function in order to facilitate an effective transport of the molecules across the skin.Microneedles are needle-like structures with the diameters in the size order of microns. The major advantage of microneedle is their ability to pierce the skin in a minimally invasive and painless way, easy to use, large scale production, and inexpensive cost. This article summarized briefl y the basics and examples of microneedles application for transdermal of DNA, for genetic diseases and vaccines.
Article Details
In the case that some parts are used by others The author must Confirm that obtaining permission to use some of the original authors. And must attach evidence That the permission has been included
References
Alzheimer’s association. Basics of alzheimer’s disease [pamphlet]. Alzheimer’s association; 2013.
Barry ME, Gonzalez DP, Orson FM, Mckenzie GJ, Petry GR, Barry MA. Role of Endogenous Endonucleases and Tissue Site in Transfection and CpG-Mediated Immune Activation after Naked DNA Injection. Hum Gene Ther 2004;10(15): 2461-80.
Cattamanchi A, Posavad CM, Wald A, Baine Y, Moses J, Higgins TJ, et al. Phase I Study of a Herpes Simplex Virus Type 2 (HSV-2) DNA Vaccine Administered to Healthy, HSV-2-Seronegative Adults by a Needle-Free Injection System. Clin Vaccine Immunol 2008;15(11):1638-43.
Chen X, Kask AS, Crichton ML, McNeilly C, Yukiko S, Dong L, et al. Improved DNA vaccination by skin-targeted delivery using dry-coated densely-packed microprojection arrays. J Control Release 2010;148(3):327-33.
CalladineCR, Drew H, Luisi B, Travers A. Understanding DNA: The Molecule and How it Works. San Diego: Elsevier Academic Press; 2004.
Donnelly JJ, Wahren B, Liu MA. DNA Vaccines: Progress and Challenges. J Immunol 2005;175(2):633-9.
Ferraro B, Morrow MP, Hutnick NA, Shin TH, Lucke CE, Weiner DB. Clinical Applications of DNA Vaccines: Current Progress. Clin Infect Dis 2011;53(3):296-302.
Fitzgerald-Hayes M, Frieda R. DNA and biotechnology. Burlington: Elsevier Academic Press; 2010.
Gill HS, Prausnitz MR. Coated microneedles for transdermal delivery. J Control Release 2007;117(2): 227-237.
Haq MI, Smith E, John DN, Kalavala M, Edwards C, Anstey A, et al. Clinical administration of microneedles: skin puncture, pain and sensation. Biomed Microdevices 2009; 11(1):35-47.
Ibraheem D, Elaissari A, Fessi H. Gene therapy and DNA delivery systems. Int J Pharm 2014;459(1–2):70-83.
Indermun S, Luttge R, Choonara YE, Kumar P, du Toit LC, Modi G, et al. Current advances in the fabrication of microneedles for transdermal delivery. J Control Release 2014;185(0):130-8.
Jhawat VC, Saini V, Kamboj S, Maggon N. Transdermal Drug Delivery Systems: Approaches and Advancements in Drug Absorption through Skin. Int J Pharm Sci Rev Res 2013;20(1): 47-56
Kendall M. Demo: A needle-free vaccine patch that’s safer and way cheaper. [Video fi le]. 2013Jun [cited 2014Nov2];Available from:URL:http://www.ted.com/talks/mark_kendall_demo_a_needle_free_vaccine_patch_that_s_safer_and_way_cheaper#
Kim NW, Lee MS, Kim KR, Lee JE, Lee K, Park JS, et al. Polyplex-releasing microneedles for enhanced cutaneous delivery of DNA vaccine. J Control Releas 2014; 179(0):11-7.
Kim Y-C, Park JH, Prausnitz MR. Microneedles for drug and vaccine delivery. Adv Drug Deliver Rev 2012a;64(14):1547-68.
Kim Y-C, Song JM, Lipatov AS, Choi SO, Lee JW, Donis RO, et al. Increased immunogenicity of avian infl uenza DNA vaccine delivered to the skin using a microneedle patch. Eur J Pharm Biopharm 2012b; 81(2): 239-247.
Kim Y-C, Suh H, Shin J. Microneedle patches for vaccine delivery. Clin Exp Vaccine Res 2014;3(1):42-9.
Koprowski H, Weiner DB. DNA Vaccination/Genetic Vaccination.Berlin: Springer; 1998.
Kumar A, Wonganan P, Sandoval MA, Li X, Zhu S, Cui Z. Microneedle-mediated transcutaneous immunization with plasmid DNA coated on cationic PLGA nanoparticles. J Control Release 2012;163(2):230-9.
Li L, Saade F, Petrovsky N. The future of human DNA vaccines. J Biotechnol 2012;162 (2-3):171-82.
Liu MA. DNA vaccines: a review. J Int Med 2003;253(4):402-10.
MacLaughlinF, Rolland A. Pharmaceutical Gene Delivery Systems. In: Rolland A, Sullivan SM, ditors.Device-Mediated Gene Delivery: A Review. United States of America: CRC Press; 2003. p. 245-77.
McCrudden MTC, McAlister E, Courtenay AJ, González-Vázquez P, Singh TRR, Donnelly RF. Microneedle applications in improving skin appearance. Exp Dermatol 2015 (in press).
Naik A, Kalia YN, Guy RH. Transdermal drug delivery: overcoming the skin’s barrier function. Pharm Sci Technal To 2000; 3(9):318-26.
Pereira VB, Zurita-Turk M, Saraiva TDL, De Castro CP, Souza BM, Agresti PM et al. DNA Vaccines Approach: From Concepts to Applications. World J Vaccine 2014; 4(2):50-71.
Schleef M. DNA Pharmaceuticals: Formulation and Delivery in Gene Therapy, DNA Vaccination and Immunotherapy. Germany: The Federal Republiic of Germany; 2005.
Shedlock DJ, Weiner DB. DNA vaccination: antigen presentation and the induction of immunity. J Leukoc Biol 2000;68(6): 793-806.
Sparber F, Tripp CH, Hermann M, Romani N, Stoitzner P. Langerhans cells and dermal dendritic cells capture protein antigens in the skin: Possible targets for vaccination through the skin. Immunobiology 2010;215(9–10):770-9.
Tuan-Mahmood TM, McCrudden MTC, Torrisi BM, McAlister E, Garland MJ, Singh TRR, et al. Microneedles for intradermal and transdermal drug delivery. Eur J Pharm Sci 2013;50(5):623-37.
van der Maaden K, Jiskoot W, Bouwstra J. Microneedle technologies for (trans)dermal drug and vaccine delivery. J Control Release 2012;161(2):645-55.
van der Maaden K, Sekerdag E, Jiskoot W, Bouwstra J. Impact-Insertion Applicator Improves Reliability of Skin Penetration by Solid Microneedle Arrays. AAPS J 2014;16(4):681-4.
Walker R, Jones S. Genes & DNA. Boston, Kingfi sher; 2003.
Watson J. DNA : the secret of life. New York: Alfred A. Knopf; 2003.
World Health Organization. Influenza at the human-animal interface [pamphlet]. World Health Organization; 2013.
Yan G, Arelly N, Farhan N, Lobo S, Li H. Enhancing DNA delivery into the skin with a motorized microneedle device. Eur J Pharm Sci 2014;52:215-22.