Outcomes of an Information System to Monitor Drug Interactions Among Patient Receiving Warfarin: Case Study of Patients Receiving Treatment at Sub-District Health Promoting Hospital
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Abstract
Warfarin is an anticoagulant which has a narrow therapeutic index. Warfarin can have interactions with other medicines. Therefore, information system should be used to monitor drug interactions. Objective: To compare the outcomes of using information system on the incidence of drug interactions and adverse events caused by warfarin-drug interactions. Method: A quasi-experimental study was designed. The sample group was patients receiving warfarin from the community hospital, who visited one of the 18 sub-district health promoting hospitals for common diseases during June to September 2021. Results: After the implementation of the information system, the incidence of prescribing drugs that interacts with warfarin reduced from 25.00% to 5.47%. The proportion of adverse reactions caused by warfarin-drug interactions also significantly reduced from 23.44 (pre-implemented) to 5.47 (post-implemented) (p<0.001). There was no serious adverse reactions caused by warfarin-drug interactions after the use of the information system. Conclusion: Using the information system can potentially reduce incidences of warfarin-drug interactions and its adverse events. This system should be promoted to be used in other sub-district health promoting hospitals.
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