Quality of life of in patients with heart failure with reduced ejection fraction
Article Sidebar
Main Article Content
Abstract
This study aimed to measure the utility by using EuroQOL five-dimensional questionnaire (EQ-5D) and to examine the factors that affected the utility of patients withheart failure with reduced ejection fraction (HFrEF) . Method: This was a cross-sectional study. The data were collected from patients with HFrEF who were followed up at the outpatient department of Maharaj Nakorn Chiang Mai Hospital from 1st July to 31st December 2015. The EQ-5D-5L questionnaire consisted of two parts, the first part consisted of five health dimensions and the second part was a health status (Visual Analog Scale, VAS). Data were analyzed using descriptive statistics. Chi-square was performed to assess relationship between utility score and patient characteristics. Results: A total of 180 CHF patients were included. Mean age was 63.1±11.7 years; 61.1% were male. The mean scores of EQ-5D and visual analog scale (VAS) were 0.88 ± 0.10 and 78.29 ±11.97, respectively. About 50% of the total samples reported that they had no problem with mobility and pain/discomfort. Approximately 60% of the total samples reported no problem with doing usual activities and no problem with anxiety/depression. Almost all samples (95.6%) reported that they had no problem with self-care. It was found that advanced age, number of comorbidities (> 4 diseases), and average number of drug dosages per day (> 6 drugs) were influential factors affecting utility scores (p-value=0.005, p-value =0.012, and p-value =0.007, respectively). The significant factors affecting the VAS score included the educational level, length of time diagnosed with heart failure and recent admission from acute decompensated heart failure, which resulted in significantly lower VAS score (p-value=0.019, p-value=0.040 and p-value= 0.040, respectively). Conclusions: Patients with chronic heart failure in this study had a relatively good quality of life. However, factors that may contribute to a decrease in quality of life include increasing age, number of comorbidities, and number of medications. The significant factors should be monitored to increase the quality of life of HFrEF patients.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
In the case that some parts are used by others The author must Confirm that obtaining permission to use some of the original authors. And must attach evidence That the permission has been included
References
Audi G, Korologou A, Koutelekos L, et al. Factors Affecting Health Related Quality of Life in Hospitalized Patients with Heart Failure. Cardiol Res Pract 2017;2017:4690458. doi: 10.1155/2017/4690458.
Berg J, Lindgren P, Mejhert M, et al. Determinants of Utility Based on the EuroQol Five-Dimensional Questionnaire in Patients with Chronic Heart Failure and Their Change Over Time: Results from the Swedish Heart Failure Registry. Value Health 2015;18(4):439-48.
Calvert MJ, Freemantle N, Cleland JG. The impact of chronic heart failure on health-related quality of life data acquired in the baseline phase of the CARE-HF study. Eur J Heart Fail 2005;7(2):243-51.
Chiaranai C, Salyer J, Best A. Self-Care and Quality of Life in Patients with Heart Failure. Thai J Nurs Res 2009; 13(4):302-17.
Comı´n-Colet J, Anguita M, Formiga F, et al. Health-related Quality of Life of Patients With Chronic Systolic Heart Failure in Spain: Results of the VIDA-IC Study. Rev Esp Cardiol 2016;69(3):256–71.
Drummond MF, Sculpher MJ, Claxton K, et al. Methods for the Economic Evaluation of Health Care Programmes (4th ed.) new York: Oxford University Press, 2015.
Gallagher AM, Lucas R, Cowie MR. Assessing health-related quality of life in heart failure patients attending an outpatient clinic:a pragmatic approach. ESC Heart Failure 2019; 6: 3–9.
Garin O, Herdman M, Vilagut G, et al. Assessing health-related quality of life in patients with heart failure: a systematic, standardized comparison of available measures. Heart Fail Rev 2014;19(3):359-67.
Gold MR, Russell LB, Siegel JE, et al. Cost-Effectiveness in Health and Medicine. New York: Oxford University Press, 1996.
Groenewegen A, Rutten FH, Mosterd A, et al. Epidemiology of heart failure. Eur J Heart Fail 2020; 22: 1342-56.
Hobbs FD, Kenkre JE, Roalfe AK, Davis RC, Hare R, Davies MK. Impact of heart failure and left ventricular systolic dysfunction on quality of life: a cross-sectional study comparing common chronic cardiac and medical disorders and a representative adult population. Eur Heart J 2002;23:1867-76.
Jonsson A, Orwelius L, Dahlstrom U, Kristenson M. Evaluation of the usefulness of EQ-5D as a patient-reported outcome measure using the Paretian classification of health change among patients with chronic heart failure. J Patient Rep Outcomes 2020;4(1):50.
Kittikraisak W, Kingkaew P, Teerawattananon Y, et al. Health related quality of life among patients with tuberculosis and HIV in Thailand. PLoS One 2012;7(1):e29775.
Kontodimopoulos N, Argiriou M, Theakos N, et al.The impact of disease severity on EQ-5D and SF-6D utility discrepancies in chronic heart failure. Eur J Health Econ 2011;12(4):383-91.
Kularatna S, Byrnes J, Chan YK, et al. Comparison of contemporaneous responses for EQ-5D-3L and Minnesota Living with Heart Failure; a case for disease specific multiattribute utility instrument in cardiovascular conditions. Int J Cardiol 2017;227:172-76.
Kularatna S, Whitty JA, Johnson NW, et al. Development of an EORTC-8D utility algorithm for Sri Lanka. Med Decis Making 2015;35(3):361-70.
Lam CSP. Heart failure in Southeast Asia: facts and numbers. ESC Heart Fail 2015;2(2):46-49.
Laothavorn P, Hengrussamee K, Kanjanavanit R, et al. Thai Acute Decompensated Heart Failure Registry (Thai ADHERE). CVD Prevention and Control 2010;5(3):89-95.
Lewis EF, Johnson PA, Johnson W, et al. Preferences for quality of life or survival expressed by patients with heart failure. J Heart Lung Transplant 2001;20:1016-24.
Mehta PA, Dubrey SW, McIntyre HF, et al. Improving survival in the 6 months after diagnosis of heart failure in the past decade: population-based data from the UK. Heart 2009;95:1851–6.
Molla S, Yitayal M, Amare G. Health-Related Quality of Life and Associated Factors Among Adult Patients with Heart Failure in Wolaita Zone Governmental Hospitals, Southern Ethiopia. Risk Manag Healthc Policy 2021;14:263-71.
Mozaffarian D, Benjamin EJ, Go AS, et al. Heart Disease and Stroke Statistics-2016 Update: A report from the American Heart Association. Circulation 2016;133:e38–e360.
Pattanaphesaj J, Thavorncharoensap M, Ramos-Goñi JM, et al. The EQ-5D-5L Valuation study in Thailand. Expert Rev Pharmacoecon Outcomes Res 2018;18(5):551-58.
Pattanaphesaj J. Health-related quality of life measure (EQ-5D-5L): measurement property testing and its preference-based score in Thai population [Doctor dissertation]; Mahidol University; 2014.
Phumart P, Limwattananon C, Kitwitee P, et al. EQ-5D-based utilities and healthcare utilization in Thai adults with chronic epilepsy. Epilepsy Behav 2018;83:140-46.
Saiguay W, Sakthong P. The psychometric testing of the Thai version of the Health Utilities Index in patients with ischemic heart disease. Qual Life Res 2013;22(7):1753-9.
Sakata Y, Shimokawa H. Epidemiology of heart failure in Asia. Circ J 2013;77:2209–17.
Sakthong P, Charoenvisuthiwongs R, Shabunthom R. A comparison of EQ-5D index scores using the UK, US, and Japan preference weights in a Thai sample with type 2 diabetes. Health Qual Life Outcomes 2008;6:71.
Sakthong P, Kasemsup V. Health utility measured with EQ-5D in Thai patients undergoing peritoneal dialysis. Value Health 2012;15(1 Suppl):S79-84.
Sakthong P, Schommer JC, Gross CR, et al. Health utilities in patients with HIV/AIDS in Thailand. Value Health 2009;12(2):377-84.
Sakthong P, Sonsa-Ardjit N, Sukarnjanaset P, et al. Psychometric properties of the EQ-5D-5L in Thai patients with chronic diseases. Qual Life Res 2015;24(12):3015-22.
Sakthong P. Mapping World Health Organization Quality of Life-BREF Onto 5-Level EQ-5D in Thai Patients With Chronic Diseases. Value Health 2021;24(8):1089-94.
Sakthong P. Measurement of clinical-effect: utility. J Med Assoc Thai 2008;91 Suppl 2:S43-52.
Spiraki C, Kaitelidou D, Papakonstantinou V, et al. Health-related quality of life measurement in patients admitted with coronary heart disease and heart failure to a cardiology department of a secondary urban hospital in Greece. Hellenic J Cardiol 2008;49(4): 241-7.
Srinonprasert V, Ratanasumawong K, Thongsri T, et al. Factors associated with low health-related quality of life among younger and older Thai patients with non-valvular atrial fibrillation. Qual Life Res 2019;28(8):2091-8.
Thorndike RM. (1978). Correlation procedures for research. New York: Gardner Press.