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Due to the current situation regarding the COVID-19 outbreak, it is important to reduce the chances of being infected or spreading COVID-19. The most effective concentration of alcohol in the disinfectants containing alcohol and water is more than 70 %(v/v). Objectives: To develop the determination of alcohol content in alcohol-based hand sanitizer products. To study the reliability of the analytical method for evaluation of the efficacy of alcohol-based hand sanitizer product. Methodology: Characterization of the physical appearance of alcohol-based hand sanitizer and raw material from community hospitals and institution in Khon Kaen provinces which were collected by the Consumer Protection Department, Khon Kaen Provincial Health Office. The proper analytical method was developed and studied about the linearity. Then the alcohol content in alcohol-based hand sanitizer products and raw materials were determined by using Gas chromatography method. Results: The linear calibration curve of standard ethyl alcohol in concentration ranges of 50 – 100 %(v/v) presented the linear equation of y = 0.0141X – 0.1023 and the correlation coefficient (r2) = 0.9994 (n = 3). For standard isopropanol alcohol solution, the standard curved was investigated in concentration ranges of 40 – 100 %(v/v). In these concentration ranges, the linear equation of isopropyl alcohol is y = 0.0137X – 0.0607 (r2 = 0.9995, n = 3). The average alcohol content in alcohol-based hand sanitizer products and raw materials were 73.8 ± 4.9 and 83.0 ± 11.5 %(v/v), respectively. Only one sample in 21 raw materials had the concentration of ethyl alcohol less than 50 %(v/v). Conclusion: The studies were found that all of the alcohol-based hand sanitizer products from community hospitals (8 samples) and institution (1 sample) in Khon Kaen province had the effective concentration of alcohol as disinfectants (not less than 70%(v/v)). For the raw materials, the only one in all samples had the concentration of ethyl alcohol under the legal limit. The results showed that all of alcohol-based hand sanitizer products from community hospitals and institution in Khon Kaen province provided the alcohol content within the effective concentration range. The application of the alcohol analytical method measured in alcohol-based hand sanitizer products can enhance consumers to access to the effective alcohol-based hand sanitizer product for prevention of COVID-19.
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