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Introduction: Hepatocellular carcinoma (HCC) in Thailand was one of leading cause of death. Currently, the guideline for diagnosis and treatment of HCC have advanced. The mortality rate was high because most patients received medical examination when cancer entered late-stage. The screening was more important in finding new cases. Therefore, the study of cost of screening for HCC at the population level will be useful for economic evaluation. Objective: To determine cost and outcome of HCC screening at Roi-Et Hospital. Methods: This is the descriptive study of the HCC screening at Roi-Et Hospital between February 2011 and November 2013. This study measured general characteristics, direct medical costs, outcome of screening and one-way sensitivity analysis. Results: There were 973 positive HBsAg patients received HCC screening with aged 44.10 ± 11.87 years and most of them are domiciled in Roi-Et Province. 120 patients were detected as positive HBeAg and 4 patients had positive hepatitis C antibody. When the screening was finished, found 9 early-stage HCC patients, 1 late-stage HCC patient and 5 cholangiocarcinoma patients. Total of medical cost was 4,776,045 baht and average medical cost was 4,908.58 baht/visit. Conclusion: Cost of treatment of HCC and cholangiocarcinoma (CCA) is higher than cost of HCC screening. Therefore, considering HCC screening at the population level will lead to early-stage HCC finding that can reduce mortality rate and cost of HCC treatment.
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