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Many Solanum fruits such as Solanum sanitwongsei W. G. Craib, Solanum stramonifolium Jacq., Solanum torvum Sw. and Solanum xanthocarpum Schrad. & H. Wendl. are consumed as traditional herbal medicine and vegetables. The present study aimed to evaluate in vitro antioxidant activities, total phenolic and flavonoid content and cytoprotective potential against tert-butyl hydroperoxide (t-BuOOH)-induced oxidative stress in a human liver cell, HepG2 of four edible fruits of Solanum (S. sanitwongsei, S. stramonifolium, S. torvum and S. xanthocarpum). Methods: Methanol was used to extract of the four Solanum fruits. In vitro antioxidant activities were evaluated for radical scavenging abilities of DPPH and ABTS and reducing power. Total phenolic and flavonoid contents were determined using the colorimetric methods of Folin-Ciocalteu and aluminium chloride, respectively. For evaluation of cytoprotective effect, cell viability was evaluated by MTT assay. Results: All four Solanum fruit extracts displayed antioxidant activities. Total phenolic and flavonoid contents were in the range of 1031.23±11.87 to 4474.36±23.74 mg GAE/100 g extract and 1283.04±12.61 to 2984.98±10.21 mg CE/100 g extract, respectively. The order of antioxidant properties and total flavonoid content was S. xanthocarpum > S. stramonifolium > S. torvum > S. sanitwongsei. Conclusion: The extracts of S. stramonifolium, S. torvum, S. sanitwongsei fruits had antioxidant potentials and cytoprotective effects against t-BuOOH in the human liver cell. They could be considered as potential sources of natural antioxidants and might be used for pharmaceutical application to treat diseases associated with oxidative stress.
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