Induction of Oxidative Stress in the Experimental Animals
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Abstract
Physical and emotional stress caused by a fast-paced life, fast food consumption habits, and living in a polluted environment, increase the risk of various chronic diseases, which results in a higher level of free radicals and lower level of antioxidants in the body. Development of an antioxidant is required to be primarily tested in an animal model before performing the clinical trial. Hence, oxidative stress induction patterns in experimental animals have been studied extensively and continuously developed to assure the treatment outcomes and/or the biological activities of the compound. The induction of oxidative stress in animal models can be conducted through the use of either drugs or chemicals, depending on the species of experimental animal, as well as the route and frequency of drug administration. The induction of oxidative stress by paracetamol, diazepam, ketoconazole, chloroquine, non-steroidal anti-inflammatory drugs (NSAIDs), diclofenac, carbon tetrachloride and heavy metals, such as chromium, cadmium, and arsenic, have been reviewed in order to inform and guide researchers who intend to implement these drugs in experimental models.
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