Alginate-magnesium aluminum silicate composite

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Thaned Pongjanyakul Pongjanyakul

Abstract


Alginate and magnesium aluminum silicate have been used as excipients in pharmaceutics. Alginate-magnesium aluminum silicate composite dispersions provided pseudoplastic flow with thixotropy because of an interaction of both materials. This led to a microcomposite formation of composite films. The composite films showed higher tensile strength and elongation, and lower drug permeability wnen compared with alginate films. The composite dispersions could be used as novel tablet coating material for modifying or sustaining drug release. Incorporation of hydrophilic plasticizers into the composite film could retard water vapor transmission and did not affect the drug permeability. Moreover, this composite could be applied to prepare small particle beads as well. Thus, alginate-magnesium aluminum silicate composite is a novel material to use as film and matrix former in pharmaceutics.


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