Effect of Alginate Film on Release Characteristics of Diclofenac Tablets Prepared using Non-aqueous Binder

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Thaned Pongjanyakul
Songkran Saengkaeo


This study investigated the cffect of alginate film on the release characteristics of sodium diclofenac tablets prepared using non-aqueous binder. The diclofenac sodium tablets with calcium gluconate were prepared using the wet granulation method and coated with sodium alginate dispersion using a diffusion- controlled interfacial complexation technique, to form insoluble alginate films. Factors affecting the drug content and drug release, such as coating time, concentration of sodium alginate dispersion, and hardcnding, were investigated. The drug content in the coated tablets was not significantly difference to that of the uncoated tablet. The release rate and initial burst release from the coated tablets were statistically lower than those from the core tablets. Both release parameters decreased with increasing coating time and concentration of sodium alginate. Moreover, the hardening process also caused a slower drug release from the coated tablets. This finding indicated that the tablets prepared using non-aqueous binder could be coated with alginate film using diffusion-controlled interfacial complexation technique. The alginate film formed could retard initial burst release and release rate of drug from the tablets.


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