Standardization of Thai Traditional Medicine Method for Treatment of Garcinia hanburuyi Hook.f Resins
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Abstract
Introduction: Garcinia hanburuyi Hook.f resin (GHR) is the exudate from G. hanburuyi stem (Clusiaceae) which is involved in various Thai traditional medicine recipes. The resin must have been treated with the specified techniques of Thai traditional medicine which are believed to reduce its toxicity or too strong activity before use. However, there has been no explanation about the properties of GHR after treatment. This study is therefore aimed to standardize of Thai traditional method for treatment of GHR. Materials and Method: The treatment of GHR was done by using the 7-layered wrapping with galanga leaves (Alpinia galanga (L.) Willd. ) or lotus leaves (Nelumbo nuclfera Gaertn) before grill and the new method of burning the aluminium foil wrapped GHR in the furnace. The HPLC chromatograms and amount of gambogic acid of GHR before and after treatments were analyzed. Results: The results showed that the optimal duration of grilling was until the sixth layer of galanga (approx. 35 min) or lotus leaves (approx. 25 min) were burned which led to the reduction of gambogic acid 30.09 % and 28.86 %, respectively. The new methods of aluminium foil wrapping when incubated at 120OC for 30 min and at 140 OC for 15 min showed the reduction of gambogic acid 29.17 %, and 29.24 %, respectively. The HPLC fingerprints of the new methods were found to similar as the traditional methods. Conclusion:The treatment processes of GHR decrease gambogic acid, a major active compound. The results are along with the Thai traditional medicine theory and could be used to explain why GHR activity could be reduced by Thai traditional treatments of GHR before uses.
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