Assessment of the Efficacy of Emulgel Contained Miracle Fruit Extract for Skin Care
Article Sidebar
Main Article Content
Abstract
Synsepalum dulcificum (miracle fruit, miracle berry) belongs to the SAPOTACEAE. From the literature review found that miracle fruit had antioxidant and anti-tyrosinase activities. The objectives of this study were to formulate the emulgel of miracle fruit extract which was a good properties and stability. The effectives of emulgel of miracle fruit extract with healthy volunteers were also investigated. Materials and methods: The miracle fruits were extracted with 95% ethanol by soxhlet extraction apparatus and evaporated. The emulgel of miracle fruit extract were formulated. The properties and stability by freeze thaw cycle of the emulgel were observed. The irritation, complacency, and efficiency test on healthy volunteers (n=30) by Cutometer MPA 580 such as Colorimeter, Corneometer, Tewameter, and Glossymeter were evaluated. Results: The miracle fruit extract was sticky and dark brown color. The percentage of yield was 36.93 %w/w. The emulgel were consisted of emulsion base and gel base in 1:7 of ratio. The physical appearance was light brown emulgel. The physical appearance, pH, and viscosity of emulgel were not significantly changed after freeze thaw cycle (P>0.05). The complacency of formulation on color and texture was moderately satisfied. However, the odor, skin penetration, and overall liking was rated as very good. None of the volunteers had skin irritation, or allergic to the test product. Therefore, the emulgel of miracle fruit have the efficiency to promote the healthy skin. The transepidermal waterloss was reduced. The brightening, moisture, and glossy of skin were increased. The healthy skin was observed after 4 weeks of emulgel continuously application (P < 0.05). Conclusions: The emulgel have a good trend to increase the healthy skin. The emulgel of miracle fruit was higher potency for skin care than emulgel base at the 4th weeks (P > 0.05). However, it is not clear how effective the skin is due to the miracle fruit extract. Therefore, it is suggested to study the use of emulgel for continuous more than 4 weeks to confirm the efficacy of emulgel of miracle fruit extract.
Article Details
In the case that some parts are used by others The author must Confirm that obtaining permission to use some of the original authors. And must attach evidence That the permission has been included
References
Chacon JRL. Miracle fruit- miracle berry (Sysepalum dulcificum Daniell)–basic aspects for contextualization. J Invest Manag 2015; 4(6): 330-333.
Chen CY, Wang YD, Wang HM. Chemical constituents from the leaves of Sysepalum dulcificum. Chem Nat Compd 2010: 46(3): 495.
Chen CY, Wu PY, Huang TS, et al. The sour taste-modifying protein (miraculin), tyrosinase inhibitors and antioxidants from Sysepalum dulcificum. Curr Nutr Food Sci 2009; 5: 1-8.
Cheng FY, Huang ST, Lin ML, et al. Polyphenol measurement and antioxidant activity of miracle fruit. Int J Chem Eng Appl 2015; 6(3): 211-214.
Chukwu CJ, Okafor CO, Nwabue FI, et al. Isolation, purification and characterization of flavor compounds in the fruit pulp of Sysepalum dulcificum. Chem Mater Res 2016; 8(8): 63-72.
Du L, Shen Y, Zhang X, et al. Antioxidant-rich phytochemicals in miracle berry (Synsepalum dulcificum) and antioxidant activity of its extracts. Food Chem 2014; 153: 279-284.
Inglett GE and Chen D. Contents of phenolics and flavonoids and antioxidant activities in skin, pulp, and seeds of miracle fruit. J Food Sci 2011; 76(3): C479-C482.
Jian H, Qiao F, Chen J, et al. Physicochemical characterization of polysaccharides from the seeds and leaves of miracle fruit (Sysepalum dulcificum) and their antioxidant and -glucosidase inhibitory activities in vitro. J Chem 2017: 1-9.
Njoku NE, Ubbaonu CN, Alagbaoso SO, et al. Proximate, anti-nutritional and phytochemical composition of the yellow variety of the Sysepalum dulcificum (miracle fruit) berry. Am J Food Sci Tech 2016; 4(4): 102-108.
Nkwocha CC, Njoku OU, Ekwueme FN. Phytochemical, antinutrient and amino acid composition of Sysepalum dulcificum pulp. J Pharm Bio Sci 2014; 9(2): 55-29.
Rowe RC, Sheskey PJ, Quinn ME. Handbook of Pharmaceutical Excipients. Sixth edition. 2009. Pharmaceutical Press, London, United Kingdom.
Shi YC, Lin KS, Jhai YF, et al. Miracle fruit (Synsepalum dulcificum) exhibits as a novel anti-hyperuricaemia agent. Molecules 2016; 21(140): 1-11.
Wang H., Chou Y., Hong Z., et al. Bioconstituents form stems of Synsepalum dulcificum Daniell (Sapotaceae) inhibit human melanoma proliferation, reduce mushroom tyrosinase activity and have antioxidant properties. J Taiwan Inst chem E 2011; 42(2): 204-211.