One-month effect methoxyflavone-enriched extract of Kaempferia parviflora on blood glucose and lipid profile in rats
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Abstract
Kaempferia parviflora is a medicinal plant that popular consuming and widely used for attenuating human health problem in Asia. The major phytochemical ingredients of K. parviflora extract are methoxyflavones. This study aimed to investigate one-month effect methoxyflavone-enriched extract of Kaempferia parviflora (KDE) on blood glucose and lipid profile in rats. The animals were randomly divided into 4 groups which were orally administered with distilled water (normal control), carboxy methyl cellulose (normal vehicle), KDE at doses of 150 and 300 mg/kg/day for 4 weeks. The results demonstrated that rats receiving KDE 300 mg/kg had significantly lower blood glucose level than normal control and normal vehicle groups (p<0.05). Both KDE150- and 300-treated rats tended to decrease the cholesterol and triglyceride levels. Level of atherogenic index in KDE300-treated rats was significantly lower than normal vehicle group. Additionally, alteration of body weight and the damaged of histological structure of liver, kidney and pancreas were not observed as compared to normal and vehicle control groups. The results suggest the safe dose and promoting health benefit in short-term administration of KDE.
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