Phenethylamine Does Not Accelerate Healing in Staphylococcus aureus-infected Wounds in Mice
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Abstract
Objective Bacterial infections can lead to a delay in the wound healing process. Recent studies have reported that trace amines accelerate wound healing by enhancing keratinocyte migration thus promoting a faster wound re-epithelization process. This study aimed to investigate the effects of phenethylamine on Staphylococcus aureus-infected wounds by using a mouse model.
Methods This study used mice as a model for in vivo skin wound experi-ments. S. aureus was applied on skin wounds on the backs of the mice. Phenethylamine in different concentrations was also applied either once daily or every two days. The wound diameter, abscess formation, and swollen area were observed every two days for 14 days.
Results Different concentrations and frequencies of phenethylamine applications on the wound exhibited no significant wound healing acceleration. Phenethylamine applications also did not show significant effects on abscess formation or swelling.
Conclusions S. aureus infection may overwhelm the wound healing acceleration effects of phenethylamine resulting in no significant improvement in healing.
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References
Rahim K, Saleha S, Zhu X, Huo L, Basit A, Franco OL. Bacterial Contribution in Chronicity of Wounds. Microb Ecol. 2017;73:710-21.
Serra R, Grande R, Butrico L, Rossi A, Settimio UF, Caroleo B, et al. Chronic wound infections: the role of Pseudomonas aeruginosa and Staphylococcus aureus. Expert Rev Anti Infect Ther. 2015;13:605-13.
Peschel A, Otto M. Phenol-soluble modulins and staphylococcal infection. Nat Rev Microbiol. 2013;11: 667-73.
Pigozzo AB, Missiakas D, Alonso S, Dos Santos RW, Lobosco M. Development of a Computational Model of Abscess Formation. Front Microbiol. 2018;9:1355. PubMed PMID: 29997587.
Luqman A, Muttaqin MZ, Yulaipi S, Ebner P, Matsuo M, Zabel S, et al. Trace amines produced by skin bacteria accelerate wound healing in mice. Commun Biol. 2020;3(1):277. PubMed PMID: 32483173
Luqman A, Ohlsen K. Adrenergic system: A gateway of reciprocal signaling between host and bacteria. Current Opinion in Endocrine and Metabolic Research. 2024;35:100523.
Luqman A, Gotz F. The Ambivalent Role of Skin Microbiota and Adrenaline in Wound Healing and the Interplay between Them. Int J Mol Sci. 2021;22:4996. PubMed PMID: 34066786.
Edwards R, Harding KG. Bacteria and wound healing. Curr Opin Infect Dis. 2004;17:91-6.
Wilgus TA, Roy S, McDaniel JC. Neutrophils and Wound Repair: Positive Actions and Negative Reactions. Adv Wound Care (New Rochelle). 2013;2:379-88.
Uberoi A, McCready-Vangi A, Grice EA. The wound microbiota: microbial mechanisms of impaired wound healing and infection. Nat Rev Microbiol. 2024;22:507-21.
Zhao R, Liang H, Clarke E, Jackson C, Xue M. Inflammation in Chronic Wounds. Int J Mol Sci. 2016;17:2085. PubMed PMID: 27973441.
Jones SG, Edwards R, Thomas DW. Inflammation and wound healing: the role of bacteria in the immuno-regulation of wound healing. Int J Low Extrem Wounds. 2004;3:201-8.
Tao Q, Ren J, Ji Z, Wang B, Zheng Y, Li J. Continuous topical irrigation for severely infected wound healing. J Surg Res. 2015;198:535-40.
