Stage-Affected Quality of Life in Endometrial Cancer Patients
Keywords:
chemotherapy, Endometrial cancer, oncology, quality of lifeAbstract
Objective This study aims to compare the aspects of quality of life between early and advanced-stage endometrial cancer patients.
Methods From January to February 2021, women diagnosed with endometrial cancer and treated at Maharaj Nakorn Chiang Mai Hospital were invited to participate. Two qualities of life questionnaires, the European
Organization for Research and Treatment of Cancer Quality of Life QLQ-C30 questionnaire (EORTC QLQ-C30) and the CMU Endometrial Cancer Quality of Life (gastrointestinal, urinary, lymphatic, sexual, and hormonal domains) were used. The chi-squared test, the Mann-Whitney U test, and multivariable linear regression were used for statistical analysis.
Results A total of 103 participants were divided into two groups: 65 individuals with early-stage disease and 38 with advanced-stage disease. All participants completed the quality-of-life questionnaires. The two groups were comparable in terms of global health status/QoL for EORTC QLQ-C30. However, the early-stage group had significantly higher functional scales and quality-of-life summary scores than the advanced-stage group. As for the CMU endometrial cancer QoL, the advanced-stage group had more negative issues related to the gynecologic and hormonal system compared to the early-stage group.
Conclusions Women with endometrial cancer generally have a good quality of life. Survivors of advanced stages may have a quality of life similar to those in the early stage but with a higher incidence of gastrointestinal, sexual, and hormonal complications.
References
Siegel R, Miller K, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70:7-30.
Thailand Source: Globocan 2020 [Internet]. World Health Organization: International Agency for Research on Cancer; 2020. [cited 2020 Dec 02]. Available from: https://gco.iarc.fr/today/data/factsheets/populations/764-thailand-fact-sheets.pdf
Jeppesen M, Jensen P, Gilså Hansen D, Iachina M, Mogensen O. The nature of early-stage endometrial cancer recurrence-A national cohort study. Eur J Cancer. 2016;69:51-60.
Tangjitgamol S, Manusirivithaya S, Srijaipracharoen S, Khunnarong J, Tanvanich S, Katanyu K, et al. Endometrial cancer in Thai women: clinico-pathological presentation and survival. Asian Pac J Cancer Prev. 2010;11:1267-72.
Amant F, Mirza MR, Koskas M, Creutzberg CL. Cancer of the corpus uteri. Int J Gynaecol Obstet. 2018; 143(Supplement_2):37-50.
Sivapornpan S, Suwannarurk K, Jaisin K, Pattaraarchachai J, Bhamarapravatana K. Comparative Study in Quality of Life between Thai Endometrial Cancer Survivors and Healthy Women in Thammasat University Hospital. Asian Pac J Cancer Prev. 2020;21:249-54.
Doğanay M, Kokanalı D, Kokanalı M, Cavkaytar S, Aksakal O. Comparison of female sexual function in women who underwent abdominal or vaginal hysterectomy with or without bilateral salpingo-oophorectomy. J Gynecol Obstet Hum Reprod. 2019;48:29-32.
Yi J, Syrjala K. Anxiety and Depression in Cancer Survivors. Med Clin North Am. 2017;101:1099-113.
Hanprasertpong J, Geater A, Jiamset I, Padungkul L, Hirunkajonpan P, Songhong N. Fear of cancer recurrence and its predictors among cervical cancer survivors. J Gynecol Oncol. 2017;28:e72. PubMed PMID: 28758378
Silpakit C, Sirilerttrakul S, Jirajarus M, Sirisinha T, Sirachainan E, Ratanatharathorn V. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30): validation study of the Thai version. Qual Life Res. 2006; 15:167-72.
Aaronson N, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85:365-76.
Charoenkwan K. CMU Cervical Cancer QoL Questionnaire [Internet]. 2018 [cited 2020 Dec 02]. Available from: http://www.wongpakaran.com/index.php?lay=show&ac=article&Id=2147598858
Herrera FG, Cruz OS, Achtari C, Bourhis J, Ozsahin M. Long-term outcome and late side effects in endometrial cancer patients treated with surgery and postoperative radiation therapy. Ann Surg Oncol. 2014;21: 2390-7.
Galaal K, Al Moundhri M, Bryant A, Lopes A, Lawrie T. Adjuvant chemotherapy for advanced endometrial cancer. Cochrane Database Syst Rev. 2014;2014: Cd010681. PubMed PMID: 24832785
Wefel J, Lenzi R, Theriault R, Davis R, Meyers C. The cognitive sequelae of standard-dose adjuvant chemotherapy in women with breast carcinoma: results of a prospective, randomized, longitudinal trial. Cancer. 2004;100:2292-9.
Sibeoni J, Picard C, Orri M, Labey M, Bousquet G, Verneuil L, et al. Patients’ quality of life during active cancer treatment: a qualitative study. BMC Cancer. 2018;18:951. PubMed PMID: 30286733
Dunberger G, Lindquist H, Waldenström AC, Nyberg T, Steineck G, Åvall-Lundqvist E. Lower limb lymphedema in gynecological cancer survivors--effect on daily life functioning. Support Care Cancer. 2013;21:3063-70.
Banning K, Fucinari J, Fielder A, Ruterbusch JJ, Beebe-Dimmer JL, Schwartz AG, et al. Quality of life in endometrial cancer survivors by grade of disease. Cancer Med. 2023;12:13675-86.
