The Impact of Maternal Age on Human Milk Composition
Keywords:
maternal age, adolescent, advanced maternal age, human milk, nutrientAbstract
Human milk provides both nutritional and non-nutritional benefits to infants and can meet an infant’s nutritional needs for the first six months of life. Human milk composition varies during lactation and is affected by maternal factors. Most investigations have reported on associations between maternal factors such as maternal diet, nutrition, and body mass index and the composition of human milk. There is, however, little information on the association between maternal age and the composition of human milk. In this review, we provide an overview of the nutrients in human milk based on maternal age relationship between nutrients in human milk and maternal age and we highlight and identify the effect of maternal age on macronutrients and micronutrients.
References
Victora CG, Bahl R, Barros AJD, França GVA, Horton S, Krasevec J et al. Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect. Lancet. 2016;387(10017):475-90.
Ip S, Chung M, Raman G, Chew P, Magula N, DeVine D, et al. Breastfeeding and maternal and infant health outcomes in developed countries. Evid Rep Technol Assess. 2007;153:1-186.
World Health Organization, United Nations Children’s Fund. Global strategy for infant and young child feeding [Internet]. WHO, UNICEF, Geneva. 2003. [cited 2020 Jul 25]. Available from: https://apps.who.int/iris/bitstream/handle/10665/42590/9241562218.pdf
World Health Organization. WHA global nutrition targets 2025: stunting policy brief. Geneva: World Health Organization; 2014. [cited 2020 Jul 25]. Available from: http://www.who.int/nutrition/topics/globaltargets_stunting_policybrief.pdf
Loaiza E, Liang M. Adolescent pregnancy: a review of the evidence [Internet]. The United Nations Population Fund (UNFPA). 2013. [cited 2020 Jul 25]. Available from: https://www.unfpa.org/sites/default/files/pub-pdf/ ADOLESCENT%20PREGNANCY_UNFPA.pdf
Division UNP. Adolescent fertility rate (births per 1,000 women ages 15-19) 2018. [cited 2020 June 10]. Available from: https://data.world bank.org/indicator/SP.ADO.TFRT
Nuampa S, Tilokskulchai F, Patil CL, Sinsuksai N, Phahuwatanakorn W. Factors related to exclusive breastfeeding in Thai adolescent mothers: concept mapping approach. Matern Child Nutr. 2019; 15:e12714.
Laopaiboon M, Lumbiganon P, Intarut N, Mori R, Ganchimeg T, Vogel JP, et al. Advanced maternal age and pregnancy outcomes: a multicountry assessment. BJOG. 2014;121 Suppl 1:49-56.
Hsieh TT, Liou JD, Hsu JJ, Lo LM, Chen SF, Hung TH. Advanced maternal age and adverse perinatal outcomes in an Asian population. Eur J Obstet Gynecol Reprod Biol. 2010;148:21-6.
Motil KJ, Kertz B, Thotathuchery M. Lactational performance of adolescent mothers shows preliminary differences from that of adult women. J Adolesc Health. 1997;20:442-9.
Marquis GS, Penny ME, Diaz JM, Marín RM. Postpartum consequences of an overlap of breastfeeding and pregnancy: reduced breast milk intake and growth during early infancy. Pediatrics. 2002;109:e56.
Demmelmair H, Koletzko B. Lipids in human milk. Best Pract Res Clin Endocrinol Metab. 2018;32:57-68.
Burdge GC, Calder PC. Introduction to fatty acids and lipids. World Rev Nutr Diet. 2015;112:1-16.
Galli C, Calder PC. Effects of fat and fatty acid intake on inflammatory and immune responses. Ann Nutr Metab.2009;55:123-39.
Kedem MH, Mandel D, Domani KA, Mimouni FB, Shay V, Marom R et al. The effect of advanced maternal age upon human milk fat content. Breastfeed Med. 2013;8:116-9.
Lubetzky R, Sever O, Mimouni FB, Mandel D. Human milk macronutrients content: effect of advanced maternal age. Breastfeed Med. 2015;10: 433-6.
Argov-Argaman N, Mandel D, Lubetzky R, Kedem MH, Cohen BC, Berkovitz Z, et al. Human milk fatty acids composition is affected by maternal age. J Matern Fetal Neonatal Med. 2017;30:34-7.
Denić M, Sunarić S, Genčić M, Živković J, Jovanović T, Kocić G, et al. Maternal age has more pronounced effect on breast milk retinol and -carotene content than maternal dietary pattern. Nutrition (Burbank, Los Angeles County, Calif). 2019;65:120-5.
Kim H, Kang S, Jung BM, Yi H, Jung JA, Chang N. Breast milk fatty acid composition and fatty acid intake of lactating mothers in South Korea. Br J Nutr. 2017;117:556-61.
Hascoet JM, Chauvin M, Pierret C, Skweres S, Egroo LV, Rouge C, et al. Impact of maternal nutrition and perinatal factors on breast milk composition after premature delivery. Nutrients. 2019;11,366.
Sinanoglou VJ, Cavouras D, Boutsikou T, Briana DD, Lantzouraki DZ, Paliatsiou S, et al. Factors affecting human colostrum fatty acid profile: a case study. PLoS One. 2017;12:e0175817.
Armand M, Bernard JY, Forhan A, Heude B, Charles MA. Maternal nutritional determinants of colostrum fatty acids in the EDEN mother-child cohort. Clin Nutr. 2018;37(6 Pt A):2127-36.
Grote V, Verduci E, Scaglioni S, Vecchi F, Contarini G, Giovannini M, et al. Breast milk composition and infant nutrient intakes during the first 12 months of life. Eur J Clin Nutr. 2016;70:250-6.
Meneses F, Torres AG, Trugo NM. Essential and long-chain polyunsaturated fatty acid status and fatty acid composition of breast milk of lactating adolescents. Br J Nutr. 2008;100:1029-37.
Wu X, Jackson RT, Khan SA, Ahuja J, Pehrsson PR. Human milk nutrient composition in the United States: current knowledge, challenges, and research needs. Curr Dev Nutr. 2018;2:nzy025.
Mohammad MA, Sunehag AL, Haymond MW. Effect of dietary macronutrient composition under moderate hypocaloric intake on maternal adaptation during lactation. Am J Clin Nutr. 2009;89: 1821-7.
Nommsen LA, Lovelady CA, Heinig MJ, Lönnerdal B, Dewey KG. Determinants of energy, protein, lipid, and lactose concentrations in human milk during the first 12 mo of lactation: the DARLING Study. Am J Clin Nutr. 1991;53:457-65.
Hahn WH, Jeong T, Park S, Song S, Kang NM. Content fat and calorie of human milk is affected by interactions between maternal age and body mass index. J Matern Fetal Neonatal Med. 2018;31:1385-8.
Bachour P, Yafawi R, Jaber F, Choueiri E, Abdel-Razzak ZJBM. Effects of smoking, mother’s age, body mass index, and parity number on lipid, protein, and secretory immunoglobulin A concentrations of human milk. Breastfeeding Med. 2012;7:179-88.
Innis SM. Perinatal biochemistry and physiology of long-chain polyunsaturated fatty acids. J Pediatr. 2003;143(4, Supplement):1-8.
Lönnerdal B. Nutritional and physiologic significance of human milk proteins. Am J Clin Nutr. 2003;77:1537S-43S.
Demmelmair H, Prell C, Timby N, Lönnerdal B. Benefits of lactoferrin, osteopontin and milk fat globule membranes for infants. Nutrients. 2017;9:817.
Dritsakou K, Liosis G, Valsami G, Polychronopoulos E, Skouroliakou M. The impact of maternal- and neonatal-associated factors on human milk’s macronutrients and energy. J Matern Fetal Neonatal Med. 2017;30:1302-8.
Mangel L, Mimouni FB, Feinstein-Goren N, Lubetzky R, Mandel D, Marom R. The effect of maternal habitus on macronutrient content of human milk colostrum. J Perinatol. 2017;37:818-21.
Burgoyne RD, Duncan JS. Secretion of milk proteins. J Mammary Gland Biol Neoplasia. 1998;3: 275-86.
Corbitt M, Paredes Ruvalcaba N, Fujita M. Variation in breast milk macronutrient contents by maternal anemia and hemoglobin concentration in northern Kenya. Am J Hum Biol. 2019;31:e23238.
Coelho AI, Berry GT, Rubio-Gozalbo ME. Galactose metabolism and health. Curr Opin Clin Nutr Metab Care. 2015;18:422-7.
Bzikowska A, Czerwonogrodzka-Senczyna A, Weker H, Wesołowska A. Correlation between human milk composition and maternal nutritional status. Rocz Panstw Zakl Hig. 2018;69:363-7.
Burianova I, Bronsky J, Pavlikova M, Janota J, Maly J. Maternal body mass index, parity and smoking are associated with human milk macronutrient content after preterm delivery. Early Hum Dev. 2019;137:104832.
Aumeistere L, Ciprovica I, Zavadska D, Andersons J, Volkovs V, Celmalniece K. Impact of maternal diet on human milk composition among lactating women in Latvia. Medicina (Kaunas). 2019;55:173.
Godoy-Parejo C, Deng C, Zhang Y, Liu W, Chen G. Roles of vitamins in stem cells. Cell Mol Life Sci. 2020;77:1771-91.
de Azeredo VB, Trugo NM. Retinol, carotenoids, and tocopherols in the milk of lactating adolescents and relationships with plasma concentrations. Nutrition (Burbank, Los Angeles County, Calif). 2008;24:133-9.
Souza G, Dolinsky M, Matos A, Chagas C, Ramalho A. Vitamin A concentration in human milk and its relationship with liver reserve formation and compliance with the recommended daily intake of vitamin A in pre-term and term infants in exclusive breastfeeding. Arch Gynecol Obstet. 2015;291:319-25.
Liyanage C, Hettiarachchi M, Mangalajeewa P, Malawipathirana S. Adequacy of vitamin A and fat in the breast milk of lactating women in south Sri Lanka. Public Health Nutr. 2008;11:747-50.
Bates CJ, Liu DS, Fuller NJ, Lucas A. Susceptibility of riboflavin and vitamin A in breast milk to photodegradation and its implications for the use of banked breast milk in infant feeding. Acta Paediatr Scand. 1985;74:40-4.
Quiles JL, Ochoa JJ, Ramirez-Tortosa MC, Linde J, Bompadre S, Battino M et al. Coenzyme Q concentration and total antioxidant capacity of human milk at different stages of lactation in mothers of preterm and full-term infants. Free Radic Res. 2006;40:199-206.
Bishara R, Dunn MS, Merko SE, Darling P. Nutrient composition of hindmilk produced by mothers of very low birth weight infants born at less than 28 weeks’ gestation. J Hum Lact. 2008;24:159-67.
Montalbetti N, Dalghi MG, Albrecht C, Hediger MA. Nutrient transport in the mammary gland: calcium, trace minerals and water soluble vitamins. J Mammary Gland Biol Neoplasia. 2014;19:73-90.
Lin TH, Jong YJ, Chiang CH, Yang MH. Longitudinal changes in Ca, Mg, Fe, Cu, and Zn in breast milk of women in Taiwan over a lactation period of one year. Biol Trace Elem Res. 1998;62:31-41.
Silvestre MD, Lagarda MJ, Farré R, Martínez-Costa C, Brines J, Molina A et al. A study of factors that may influence the determination of copper, iron, and zinc in human milk during sampling and in sample individuals. Biol Trace Elem Res. 2000;76:217-27.
Severi C, Hambidge M, Krebs N, Alonso R, Atalah E. Zinc in plasma and breast milk in adolescents and adults in pregnancy and postpartum: a cohort study in Uruguay. Nutr Hosp. 2013;28:223-8.
Rodríguez Rodríguez EM, Sanz Alaejos M, Díaz Romero C. Concentrations of iron, copper and zinc in human milk and powdered infant formula. Int J Food Sci Nutr. 2000;51:373-80.
Lee S, Hennigar SR, Alam S, Nishida K, Kelleher SL. Essential role for zinc transporter 2 (ZnT2)-mediated zinc transport in mammary gland development and function during lactation. J Biol Chem. 2015;290:13064-78.
Ballard O, Morrow AL. Human milk composition: nutrients and bioactive factors. Pediatr Clin North Am. 2013;60:49-74.
Mohammad MA, Sunehag AL, Haymond MW. De novo synthesis of milk triglycerides in humans. Am J Physiol Endocrinol Metab. 2014;306:E838-47.
Marvin-Dowle K, Burley VJ, Soltani H. Nutrient intakes and nutritional biomarkers in pregnant adolescents: a systematic review of studies in developed countries. BMC Pregnancy Childbirth. 2016;16:268.
Rah JH, Christian P, Shamim AA, Arju UT, Labrique AB, Rashid M. Pregnancy and lactation hinder growth and nutritional status of adolescent girls in rural Bangladesh. J Nutr. 2008;138:1505-11.
Lunn PG, Austin S, Prentice AM, Whitehead RG. The effect of improved nutrition on plasma prolactin concentrations and postpartum infertility in lactating Gambian women. Am J Clin Nutr. 1984;39:227-35.
Konner M, Worthman C. Nursing frequency, gonadal function and birth spacing among Kung hunter gatherers. Science. l980;207:788-91.
Shermak MA. Congenital and developmental abnormalities of the breast. Management of breast diseases. Switzerland: Springer; 2010. p. 37-51.
De Tata V. Age-Related Impairment of Pancreatic Beta-Cell Function: Pathophysiological and Cellular Mechanisms. Front Endocrinol (Lausanne). 2014;5:138.
