รูปแบบการใช้ยากระตุ้นการหลั่งน้ำนมในมารดาให้นมบุตร: รูปแบบการใช้ยากระตุ้นการหลั่งน้ำนม

Phithakham C; Kritsadathan T; Puakmuangpol J; Ngenkhamkong K; Kanjanarat P

Authors

Phithakham C Division of Pharmacy, Maharaj Nakorn Chiang Mai Hospital, Faculty of Medicine, Thailand
Kritsadathan T Division of Pharmacy, Maharaj Nakorn Chiang Mai Hospital, Faculty of Medicine, Thailand
Puakmuangpol J Division of Pharmacy, Maharaj Nakorn Chiang Mai Hospital, Faculty of Medicine, Thailand
Ngenkhamkong K Division of Pharmacy, Maharaj Nakorn Chiang Mai Hospital, Faculty of Medicine, Thailand
Kanjanarat P Faculty of Pharmacy, Chiang Mai University, Thailand

Keywords:

breast feeding, galactagogue, domperidone

Abstract

Objectives To identify patterns of drug prescribing to promote lactation in breastfeeding mothers. Methods A cross-sectional descriptive study was conducted using retrospective data collection from electronic medical records from January – December 2017.

Results Of 1,494 mothers who gave birth, 136 received a galactagogue. The prescription rate was 9.10% with all doctors prescribing domperidone. Most of prescriptions indicated use in the hospital and following discharge (52.21%) and almost all mothers (98.55%) were evaluated before being given a prescription and most mothers had breast milk levels of 0 (34.78%) and received at least one intervention to help promote lactation (100%). The majority were prescribed 30 mg of domperidone per day (64.71%). All received domperidone within 10 days after giving birth and the mean day they received domperidone was on day 6.

Conclusion The rate of prescribing to promote lactation in breast feeding mothers was 9.10, with all doctors prescribing domperidone. Almost all mothers receiving a galactagogue were evaluated first and received at least one intervention to help promote lactation before being prescribed medication. Domperidone prescriptions were given within 10 days after birth and the mean day that mothers received domperidone was 6.19

References

1. World Health Organization. Infant and Young child Nutrition: Global Strategy on Infant and Young Child Feeding. 55th World Health Assembly. Geneva:WHO 2002.
2. Dorovan TJ, Buchanan K. Medications for increasing milk supply in mothers expressing breastmilk for their preterm hospitalised infants. Cochrane Database Sys Rev 2012;3:Cd005544.
3. Ingram J, Taylor H, Churchill C, Pike A, Greenwood R. Metoclopramide or domperidone for increasing maternal breast milk output: a randomised controlled trial. Arch Dis Child 2011;97(4):F241-5.
4. Drug facts and comparisons. St. Louis, MO: Facts and Comparisons 1999.
5. Hale TW. Medications and Mother's Milk. th, editor. Texas: Hale Publishing; 2008 ; p 1172.
6. Osadchy A, Moretti ME, Koren G. Effect of domperidone on insufficient lactation in puerperal women: a systematic review and meta-analysis of randomized controlled trials. Obstet Gynecol Int J 2012;2:642893.
7. สรียา เวชวิฐาน, ภควดี ศรีภิรมย์. Domperidone : คำเตือนที่ฉลากและเอกสารกำกับยา. ข่าวสารด้านยาและผลิตภัณฑ์สุขภาพ 19(4):97-100.
8. Petraglia F, de Leo V, Sardelli S and et al. Domperidone in defective and insufficient lactation. Eur J Obstet Gynecol Reprod Biol 1985;19:281-7.
9. da Silva OP, Knoppert DC, Angelini MM, Forret PA. Effect of domperidone on milk production in mothers of premature newborns: a randomized, double-blind, placebo-controlled trial. CMAJ 2001;164(1):17-21.
10. Campbell-Yeo ML, Allen AC, Joseph KS, Ledwidge JM, Caddell K, Allen VM, et al. Effect of domperidone on the composition of preterm human breast milk. Pediatrics 2010;125(1):e107-14.
11. Jantarasaengaram S, Sreewapa P. Effect of domperidone on augmentation of lactation following cesarean delivery at full term. Int J Gynaecol Obstet 2012;116:240-3.
12. The Academy of Breastfeeding Medicine. ABM Clinical Protocol #9: Use of Galactogogues in Initiating or Augmenting the Rate of Maternal Milk Secretion (First Revision January 2011). Breastfeeding Medicine 2011;6(1):41- 9.
13. Charles F. Lacy LLA, Morton P. Goldman, Leonard L. Lance. Drug Information Handbook. In: 19th, editor. America: Lexi-Comp; 2010-2011:519-20.
14. ภูขวัญ อรุณมานะกุล. How safe to use domperidone in stimulating for breast feeding woman. สมาคมเภสัชกรรมโรงพยาบาล (ประเทศไทย).2559;144-150.
15. Chongtrakul P. RDU hospital : the pathway to rational drug use. Thai Journal of Pharmacology 2015;37:48-62.
16. Committee on National Drug System Development. National drug policy B.E. 2554 and strategies for drug system developemtn B.E. 2555-2559. Bangkok: Pulishing House of Agricultural Cooperative Federation of Thailand 2011.
17. Public Administration Division. Service plan : rational drug use. Nontraburi: Ministry of Public Health 2016.
18. Smolina K, Morgan SG, Hanley GE, Oberlander TF, Mintzes B. Postpartum domperidone use in British Columbia: a retrospective cohort study. CMAJ open. 2016;4(1):E13-9.
19. Grzeskowiak LE, Lim SW, Thomas AE, Ritchie U, Gordon AL. Audit of domperidone use as a galactogogue at an Australian tertiary teaching hospital. J Hum Lact. 2013;29(1):32-7.
20. Wan EW, Davey K, Page-Sharp M, Hartmann PE, Simmer K, Ilett KF. Dose-effect study of domperidone as a galactogogue in preterm mothers with insufficient milk supply, and its transfer into milk. Dr J Clin Pharmacol. 2008; 66:283-9.
21. วิไล เชตะวัน, มนตรี วังพฤกษ์. การใช้ยากระตุ้นน้ำนม domperidone ในคลินิกนมแม่
โรงพยาบาลส่งเสริมสุขภาพ ศูนย์อนามัยที่ 10 เชียงใหม่ [อินเทอร์เน็ต].[เข้าถึงเมื่อ 24 มีนาคม2562]. เข้าถึงจาก: URL :https://www.breastfeedingthai.com/%E0%B8%A2%E0%B8%B2%E0%B9%80%E0%B8%9E%E0%B8%B4%E0%B9%88%E0%B8%A1%E0%B8%99%E0%B9%89%E0%B8%B3%E0%B8%99%E0%B8%A1-domperidone-motilium.html