Agreement and correlation between PHQ-9 and HAMD in patients in remission or with mild symptoms of major depressive disorder

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Orawan Silpakit
Paitoon Samuthrsindh
Rossukon Chomchuen


Objective:  To analyze the agreement and correlation between the sum scores of Patient Health Questionnaire (PHQ-9) and Hamilton Depression Rating Scale (HAMD) in patients in remission or with mild symptoms of major depressive disorder  attending the outpatient service of Srithanya Hospital from June to September 2021.

Methods:  Secondary data were obtained from 107 patients with HAMD-17 scores of 18 points or less. PHQ-9 and HAMD-17 were applied by interviewing the patient during the same visit. Descriptive statistic was used. The coefficient correlations were analyzed by intraclass correlation (ICC) and Pearson’s r among PHQ-9, HAMD-17, and selected items of HAMD such as HAMD-6 and HAMD part anxiety-depression (HAMD-AD).

Results: Most patients were female (69.4%) and had been diagnosed with a single episode of major depression (F32) at 74.8%. The mean age was 36.9 years old. The mean scores of PHQ-9, HAMD-17 were 7±2.8 & 9.1±3.8, respectively. ICC(95%CI) between HAMD-17 & PHQ-9, HAMD-6&PHQ-9, HAMD-AD& PHQ-9 were 0.79 (0.65,0.84), 0.85(0.79,0.90) & 0.91(0.86, 0.94), respectively. Pearson’s r ranged from 0.54 to 0.68.

Conclusion: The sum scores of PHQ-9 were strongly concordant with those of HAMD-17, HAMD-6, and HAMD-AD in major depressive patients who were in remission or presented mild symptoms.


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