New agents for treatment of pelvic endometriosis (ยาชนิดใหม่สำหรับการรักษาเยื่อบุโพรงมดลูกเจริญผิดที่ในอุ้งเชิงกราน)

Abstract

Endometriosis is an estrogen dependent disorder that needs long term treatment. The primary goal of treatment is to alter the growth and activity of endometriotic lesions by inhibiting ovulation and/or inducing atrophic endometrium. Increasing knowledge of the pathogenesis of endometriosis at the molecular and cellular levels has given the opportunity to develop new therapeutic agents. Which have greater efficacy and flexibility than traditional treatments. The new agents are classified as anti-estrogen, anti-progesterone, angiogenesis inhibitors, immunomodulating agents and anti-inflammatory drugs. This review focuses on the new experimental approaches to the medical treatment of pelvic endometriosis.