Current management for acute hepatic failure (การรักษาภาวะตับวายเฉียบพลัน)

Authors

  • Lakkana Rerksuppaphol
  • Sanguansak Rerksuppaphol

Keywords:

Acute hepatic failure, coagulopathy, encephalopathy, cerebral edema, targets

Abstract

Acute hepatic failure is one of the rare disease, but is life-threatening. The present review summarizes about the acute hepatic failure in relation to various treatments available depending upon the complications such as cerebral edema, hepatic encephalopathy, renal dysfunction etc. The gold standard treatment for acute hepatic failure is “orthotopic liver transplantation”. Other treatments include uses of dialysis techniques to remove hepatotoxins, antibiotics and drugs for inflammatory mediators depending upon various etiologies. As the present therapies are associated with various drawbacks, some future therapeutic targets such as cannabinoid receptors, gene therapy and aquaporin channels are also discussed which are in preclinical stages.

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Author Biographies

Lakkana Rerksuppaphol

Department of Preventive Medicine, Faculty of Medicine, Srinakharinwirot University

Sanguansak Rerksuppaphol

Department of Pediatrics, Faculty of Medicine, Srinakharinwirot University

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Section

Review Article (บทความวิชาการ)