Obesity and cardiovascular diseases
Keywords:
obesity, cardiovascular diseases, atherosclerosis, heart failure, arrhythmiaAbstract
The global obesity crisis remains a pressing issue, contributing to various cardiovascular risk factors such as dyslipidemia, type 2 diabetes, hypertension, and sleep disorders. Moreover, obesity independently escalates the risk of cardiovascular disease and related mortality. Recent findings emphasize the significance of abdominal obesity, assessed by waist circumference, as an independent marker for cardiovascular disease risk, distinct from body mass index. There have been notable advancements in characterizing body composition, including visceral adiposity, which highlight its role as a crucial factor in predicting poor cardiovascular outcomes. Lifestyle changes and subsequent weight loss can improve metabolic syndrome, systemic inflammation, and endothelial dysfunction. However, clinical trials focusing on medical weight loss have not demonstrated a reduction in coronary artery disease rates. In contrast, comparative studies between individuals undergoing bariatric surgery and those with obesity not undergoing surgery have shown a decreased risk of coronary artery disease with surgery. This article provides a comprehensive overview of how obesity impacts the diagnosis, clinical management, and outcomes of atherosclerotic cardiovascular disease, heart failure, and arrhythmias, including sudden cardiac death and atrial fibrillation. It also discusses the effects of lifestyle changes and surgical weight loss interventions on outcomes related to coronary artery disease, heart failure, and atrial fibrillation.
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