Human metabolite profiling changes with organic food consumption for 7 and 30 days: A pilot study
Keywords:
organic food, healthy food, body mass index, metabolite compoundsAbstract
Abstract
Organic food consumption is a growing interest worldwide. The aim of this study is to assess overall metabolite changes that occur during organic food consumption. The Thai adult participants were classified into two groups, with a normal or at-risk health status, and then provided with a diet containing organic foods for 7 and 30 days. Health checkups,including blood and urine sampling, were performed at 0, 7 and 30 days. The effects on body weight, body mass index, the basal metabolic rate and zinc concentrations showed significantdifferences after 30 days. Urine metabolite profiling showed some changes related to human metabolic pathways. Organic food consumption was associated with higher levels of nicotinamidebeta-riboside, biliverdin, octadecanoic acid, 2-methyl-1-hydroxybutyl-ThPP, s-adenosyll-homocysteine, 2,3-diketo-5-methylthiopentyl-1-phosphate, fumarate and pyridoxal phosphate and lower levels of allopregnanolone, dolichyl beta-d-glucosyl phosphate, corticosterone, dehydroepiandrosterone sulfate, n-carbamoyl-l-aspartate and leukotriene C4. The observed metabolite changes might indicate the health-related impact of organic food consumption.
References
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cholesterol excretion in healthy elderly volunteers. Nutr J 2007;42:1-7.
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2. Ren F, Reilly K, Kerry JP, et al. Higher antioxidant activity, total flavonols, and specific quercetin glucosides in two different onion (Allium cepa L.) varieties grown under organic production: Results from a 6-year field study. J Agric Food Chem 2017;65:5122-32.
3. Baudry J, Assmann KE, Touvier M, et al. Association of frequency of organic food consumption with cancer risk: Findings from the NutriNet-Sante prospective cohort study. JAMA Intern Med 2018;178:1597-606.
4. Di Renzo L, Di Pierro D, Bigioni M, et al. Is antioxidant plasma status in humans a consequence of the antioxidant food content influence? Eur Rev Med Pharmacol Sci 2007;11:185-92.
5. Crinnion WJ. Organic foods contain higher levels of certain nutrients, lower levels of pesticides, and may provide health benefits for the consumer. Altern Med Rev 2010;15:4-12.
6. Wald C. Diagnostics: A flow of information.Nature 2017;551:S48-s50.
7. Dettmer K, Aronov PA, Hammock BD. Mass spectrometry-based metabolomics. Mass Spectrom Rev 2007;26:51-78.
8. Toaldo IM, Cruz FA, da Silva EL, et al. Acute consumption of organic and conventional tropical grape juices (Vitis labrusca L.) increases antioxidants in plasma and erythrocytes, but not glucose and uric acid levels, in healthy individuals. Nutr Res 2016;36:808-17.
9. Mie A, Andersen HR, Gunnarsson S, et al. Human health implications of organic food and organic agriculture:a comprehensive review. Environ Health 2017;16:111.
10. Pashkov V, Batyhina O, Leiba L. Ensuring right to organic food in public health system. Wiad Lek 2018;71(1 pt 2):226-9.
11. Zhou L, Xu J-D, Zhou S-S, et al. Independent or integrative processing approach of metabolite datasets from different biospecimens potentially affects metabolic pathway recognition in metabolomics. J Chromatogr A 2019;1587:146-54.
12. Goetzke B, Nitzko S, Spiller A. Consumption of organic and functional food. A matter of well-being and health? Appetite 2014;77:94-103.
13. De Lorenzo A, Noce A, Bigioni M, et al. The effects of Italian Mediterranean organic diet (IMOD) on health status. Curr Pharm Des 2010;16:814-24.
14. Baudry J, Lelong H, Adriouch S, et al. Association between organic food consumption and metabolic syndrome: cross-sectional results from the NutriNetSante study. Eur J Nutr 2018;57:2477-88.
15. Mrazova J, Gazarova M, Kopcekova J, et al. The effect of consumption of pork enriched by organic selenium on selenium status and lipid profile in blood serum of
consumers. J Environ Sci Health B 2020; 55:69-74.
16. Bradbury KE, Balkwill A, Spencer EA, et al. Organic food consumption and the incidence of cancer in a large prospective study of women in the United Kingdom. Br J 2014;110:2321-6.
17. Ciudad-Mulero M, Matallana-Gonzalez MC, Camara M, et al. Antioxidant phytochemicals in pulses and their relation to human health: A review. Curr
Pharm 2020.
18. Chi Y, Sauve AA. Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection. Curr Opin Clin Nutr Metab Care 2013;16:657-61.
19. Gilmour BC, Gudmundsrud R, Frank J, et al. Targeting NAD(+) in translational research to relieve diseases and conditions of metabolic stress and ageing. Mech Ageing
Dev 2020;186:111208.
20. Brown KD, Maqsood S, Huang JY, et al. Activation of SIRT3 by the NAD(+) precursor nicotinamide riboside protects from noiseinduced hearing loss. Cell metabolism
2014;20:1059-68.
21. McDonnell MC, Mohiuddin SS. Biochemistry, Biliverdin. StatPearls. Treasure Island (FL): StatPearls Publishing LLC.; 2020.
22. Bali A, Jaggi AS. Multifunctional aspects of allopregnanolone in stress and related disorders. Prog Neuropsychopharmacol Biol Psychiatry 2014;48:64-78.
23. Sundstrom Poromaa I, Comasco E, Backstrom T, et al. Negative association between allopregnanolone and cerebral serotonin transporter binding in healthy women of fertile age. Front Psychol 2018;9:2767.
24. Brunton PJ, McKay AJ, Ochedalski T,et al. Central opioid inhibition of neuroendocrine stress responses in pregnancy in the rat is induced by the neurosteroid allopregnanolone.J Neurosci 2009;29:6449-60.
25. Bin P, Huang R, Zhou XA-O. Oxidation resistance of the sulfur amino acids: Methionine and cysteine. Biomed Res Int 2017;27:2314-6141.
26. Manuel AM, Walla MD, Faccenda A, et al. Succination of protein disulfide isomerase links mitochondrial stress and endoplasmic reticulum stress in the adipocyte during
Diabetes. Antioxid Redox Signal 2017;27:1281-96.
27. Manuel AM, Walla MD, Dorn MT, et al.Fumarate and oxidative stress synergize to promote stability of C/EBP homologous protein in the adipocyte. Free Radic Biol
Med 2020;148:70-82.
28. Mannella P, Simoncini T, Caretto M, et al. Dehydroepiandrosterone and cardiovascular disease. Vitam Horm 2018;108:333-53.
29. Gartside SE, Griffith NC, Kaura V, et al. The neurosteroid dehydroepiandrosterone (DHEA) and its metabolites alter 5-HT neuronal activity via modulation of GABAA
receptors. J Psychopharmacol 2010;24:1717-24.
30. van Rooijen MA, Mensink RP. Palmitic acid versus stearic acid: Effects of interesterification and intakes on cardiometabolic risk markers - A systematic review. Nutrients 2020;12.
31. Holecek MA-O. Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements. Nutr Metabclond 2018;33: 1743-7075.
32. Herscovics A Fau - Bugge B, Bugge B Fau -Jeanloz RW, Jeanloz RW. Glucosyltransferase activity in calf pancreas microsomes. Formation of dolichyl D[14C]
glucosyl phosphate and 14C-labeled lipidlinked oligosaccharides from UDP-D-[14C] glucose. (0021-9258 (Print)).
33. Hoving LR, Katiraei S, Heijink M, et al.Dietary mannan oligosaccharides modulate gut microbiota, increase Fecal bile acid excretion, and decrease plasma cholesterol and atherosclerosis Development. Mol Nutr Food Res 2018;62:1613-4133.
34. Bouhnik Y, Achour L Fau - Paineau D, et al. Four-week short chain fructooligosaccharides ingestion leads to increasing fecal bifidobacteria and
cholesterol excretion in healthy elderly volunteers. Nutr J 2007;42:1-7.
35. Stahn C, Buttgereit F. Genomic and nongenomic effects of glucocorticoids. Nat Clin Pract Rheumatol 2008;4:525-33.
36. Badr AM, Attia HA, Al-Rasheed N. Oleuropein reverses repeated corticosterone-induced depressive-like behavior in mice: Evidence of modulating effect on biogenic Sci Rep 2020;10:3336.
37. Clayton PT. B6-responsive disorders: a model of vitamin dependency. J Inherit Metab Dis 2006;29:317-26.
38. Ueland PM, McCann A, Midttun Ø, et al. Inflammation, vitamin B6 and related pathways. Mol Aspects Med 2017;53:10-27.
39. Dvash E, Har-Tal M, Barak S, et al. Leukotriene C4 is the major trigger of stress-induced oxidative DNA damage. Nat Commun 2015;6:10112.
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Published
2021-12-30
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Lalitmanat S, Pannengpetch S, Suksrichavalit T, Khaokhiew T, Isarankura-Na-Ayudhya C, Navaraj A, Suwanjang W. Human metabolite profiling changes with organic food consumption for 7 and 30 days: A pilot study. J Med Health Sci [Internet]. 2021 Dec. 30 [cited 2024 Dec. 19];28(3):75-89. Available from: https://he01.tci-thaijo.org/index.php/jmhs/article/view/254018
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