Safety of a high absorption pad for blood and pus with silk sericin and chitosan
Keywords:
high absorption pad, blood and pus, silk sericin, chitosan, safetyAbstract
High absorption pad for blood and pus with silk sericin and chitosan was developed to enhance absorption properties and non-adhesion. It reduced pain while dressing and had anti-bacterial property identical to Bactigras®. This study is the clinical evaluation of the high absorption pad for blood and pus with silk sericin and chitosan to confirm its safety in comparison with Bactigras® (control group, standard treatment) which requires investigation before clinical efficacy evaluation. The safety test was conducted on 100 healthy volunteers and performed using a patch model. The induction phase used a high absorption pad for blood and pus with silk sericin and chitosan and Bactigras® for six days then removed the dressing for 7-10 days. After that, the dressing was repeated for 3 days (challenge phase). The erythema index and melanin index were evaluated for skin inflammation and post-inflammation hyperpigmentation. There was no significant increase in erythema and the melanin index between each phase. There was evidence of mild erythema and itching on the skin patched with a high absorption pad for blood and pus with silk sericin and chitosan and Bactigras® and no evidence of severe cutaneous reactions was found. Therefore, these results confirmed that a high absorption pad for blood and pus with silk sericin and chitosan was safe for the treatment of wound.
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