Safety of a high absorption pad for blood and pus with silk sericin and chitosan
High absorption pad for blood and pus with silk sericin and chitosan was developed to enhance absorption properties and non-adhesion. It reduced pain while dressing and had anti-bacterial property identical to Bactigras®. This study is the clinical evaluation of the high absorption pad for blood and pus with silk sericin and chitosan to confirm its safety in comparison with Bactigras® (control group, standard treatment) which requires investigation before clinical efficacy evaluation. The safety test was conducted on 100 healthy volunteers and performed using a patch model. The induction phase used a high absorption pad for blood and pus with silk sericin and chitosan and Bactigras® for six days then removed the dressing for 7-10 days. After that, the dressing was repeated for 3 days (challenge phase). The erythema index and melanin index were evaluated for skin inflammation and post-inflammation hyperpigmentation. There was no significant increase in erythema and the melanin index between each phase. There was evidence of mild erythema and itching on the skin patched with a high absorption pad for blood and pus with silk sericin and chitosan and Bactigras® and no evidence of severe cutaneous reactions was found. Therefore, these results confirmed that a high absorption pad for blood and pus with silk sericin and chitosan was safe for the treatment of wound.
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