Anti-cancer effect of Moringa oleifera leaf extract on squamous cell carcinoma 15 cells

Authors

  • Daranphop Doungdet
  • Weeraluck Unnoi
  • Thitiya Luetragoon
  • Kanchana Usuwanthim
  • Pachuen Potup

Keywords:

Moringa oleifera Lam., squamous cell carcinoma 15 cells, apoptosis

Abstract

Abstract
Moringa oleifera Lam. is widely cultivated in tropical area for food source. Moreover, it has anti-inflammation, antioxidant, anti-bacterial and anti-cancer properties. Cancer is the first cause of death in Thailand including lung cancer, liver cancer, breast cancer and head and neck cancer respectively. In this study, we aimed to investigate the anti-cancer property of Moringa oleifera Lam. leaf extract on head and neck cancer cell line using squamous cell carcinoma (SCC) 15 cells. M. oleifera leaves crude hexane extract were tested with SCC15 cells and human macrophages by cytotoxicity assay. A five percent inhibitory concentration          (IC5) of macrophages was used to evaluate the anti-cancer activity on SCC15 cells. Cell apoptosis were anayzed by Muse™ Annexin V and Dead Cell Kit. Results showed that the extract could significantly induce cancer cell apoptosis same as cisplatin compare to untreated control (p<0.05). In conclusion, result suggested that M. oleifera leaf extracts potentially have anti-cancer property on SCC15 cells. Thus, it should be further identified the bioactive compounds and elucidate the mechanism of anti-cancer activity. The findings imply that M. oleifera leaf extract is anti-cancer effect which might develop a new drug for head and neck cancer.

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References

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Published

2020-12-30

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Original Article (บทความวิจัย)