Virulence factors of foodborne pathogenic Vibrio parahaemolyticus

Authors

  • Kaknokrat Chonsin

Keywords:

Vibrio parahaemolyticus, virulence factors, TDH, TRH, T3SS

Abstract

บทคัดย่อ
Vibrio parahaemolyticus เป็นหนึ่งในสาเหตุหลักของการระบาดของโรคอาหารเป็นพิษหรือโรคกระเพาะอาหารและลำไส้อักเสบในประเทศไทยและประเทศอื่นๆ ซึ่งเกิดจากการบริโภคอาหารทะเลแบบดิบ หรือกึ่งสุกกึ่งดิบ การแพร่กระจายของการติดต่อของเชื้อ V. parahaemolyticus สายพันธุ์ต่างๆ ในคนและสิ่งแวดล้อมซึ่งเกี่ยวข้องกับปัจจัยก่อโรคนั้นยังคงมีการศึกษาค้นคว้าต่อไป บทความนี้กล่าวถึงปัจจัยก่อความรุนแรงของโรคที่สำคัญของแบคทีเรีย V. parahaemolyticus สายพันธุ์ก่อโรค อันประกอบด้วย สารพิษ 2 ชนิด คือ thermostable direct hemolysin (TDH) และ thermostable direct-related hemolysin (TRH) กับระบบขนส่งโปรตีน type three secretion system (T3SS) 2 ระบบ คือ ระบบที่ 1 T3SS1 และระบบที่ 2 T3SS2 จากการศึกษาคุณสมบัติของปัจจัยก่อความรุนแรงของโรคแต่ละชนิดพบว่า สารพิษ TDH กับ TRH และ ระบบขนส่งโปรตีน T3SS2 มีผลให้เกิดอุจจาระร่วง (enterotoxicity) สำหรับระบบขนส่งโปรตีน T3SS1 ทำให้เกิดการตายของเซลล์ (cytotoxicity) และส่งเสริมให้แบคทีเรียมีชีวิตรอดในเซลล์โฮสต์ได้ การใช้ตัวติดตามปัจจัย รุนแรงในการก่อโรคของสายพันธุ์ก่อโรคจะเป็นประโยชน์สำหรับการเฝ้าระวังทางระบาดวิทยาและการติดตามสายพันธุ์

Abstract
Vibrio parahaemolyticus is one of the major causes of food poisoning or gastroenteritis outbreaks in Thailand and other countries due to the improper seafood consumption. The spread of transmission of V. parahaemolyticus strains in humans and environments and their virulence factors remains to be established. This study reviewed the virulence factors of pathogenic V. parahaemolyticus strains which composed of 2 hemolysins, thermostable direct hemolysin (TDH) and thermostable direct-related hemolysin (TRH), as well as 2 kinds of type three secretion system (T3SS), T3SS1 and T3SS2. The TDH, TRH and T3SS2 cause enterotoxicity while the T3SS1 contributes to cytotoxicity and enhances the survival of bacteria in host cells. More significantly, probing the virulence factors of pathogenic strains would be essential for the epidemiological surveillance and monitoring.

 

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Published

2020-04-29

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Section

Review Article (บทความวิชาการ)