A comparative sterility of the hospital preparation fortified antibiotic eye drops between preparing under laminar flow cabinet and normal airflow condition

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พรรณลักษณ์ สินสวัสดิ์
วิวัฒน์ ประเสริฐ

Abstract

Sometimes it is unable to cure corneal ulcer for some patients by using commercial
antibiotic eye drops. Thus, it is necessary to apply the intravenous antibiotics mixed
to eye drops for patients in order to reduce any side effects from the commercial antibiotic
eye drops. During the process of drug preparation, there is a chance for contamination.
Each hospital has different process to prepare the medicine depending on the limitation
in resources. This study aims to compare the results of the contamination during the drug
preparation process by using Sterile technique in the normal airflow condition and by using
laminar airflow cabinet system at the Maha Chakri Sirindhorn Medical Center. To compare
the results of the contamination during the fortified antibiotic eye drops preparation process
by using Sterile technique in the normal airflow condition and by using laminar airflow
cabinet system. Prospective observational study conducted the experiment over a 28-day
period by studying Amikacin and Cefazolin. The control group used laminar airflow cabinet
system. The intervention group used Sterile technique in the normal airflow condition.
which had different environmental factors including temperature, humidity and the quantity
of particle within the research site. There were 25 Amikacin and 25 Cefazolin eye drops
from two sample groups. They were then culture in the Tryptic soy broth, Thioglycolate
broth on Day 0, 3, 7, 14 and 28. The result from the study revealed that there was no
statistical significance of the growth of bacteria between antibiotic eye drops mixed under
the laminar airflow cabinet system and that mixed under the normal airflow condition.
There was no growth of organisms from both sample groups (p=1.00). However, it found
that culture plates became less clear. When subculture, there was no growth among these
two sample groups. There was no statistical significance of the growth of bacteria from
between antibiotic eye drops mixed under the laminar airflow cabinet system and that
mixed under the normal airflow condition at the Maha Chakri Sirindhorn Medical Center.

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Original Article (บทความวิจัย)

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