Paraneoplastic Cerebellar Degeneration with Anti-Yo Antibody in a Patient with Fallopian Tube Adenocarcinoma: A Case Report and Literature Review

Jirayu Sae-Chan; Supakorn Yamuthai; Thanyalak Amornpojnimman; Prut Koonalinthip

doi:10.31584/jhsmr.20241126

Authors

Jirayu Sae-Chan Division of Neurology, Department of Internal Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
Supakorn Yamuthai Division of Neurology, Department of Internal Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
Thanyalak Amornpojnimman Division of Neurology, Department of Internal Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
Prut Koonalinthip Division of Neurology, Department of Internal Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.

DOI:

https://doi.org/10.31584/jhsmr.20241126

Keywords:

anti-Yo antibody, gynecologic malignancy, paraneoplastic cerebellar degeneration, paraneoplastic neurological syndrome

Abstract

Paraneoplastic cerebellar degeneration (PCD) typically presents via acute to subacute cerebellar ataxia, dysarthria, and ocular dysmetria, resulting from tumor-induced autoimmunity against the cerebellum. In most cases, symptoms of PCD show months before a diagnosis of cancer. Therefore, it is important for clinicians to investigate the primary tumor in PCD cases in order to treat both conditions concurrently. Herein, we report a case of PCD associated with an anti-Yo antibody, leading to a diagnosis of left fallopian tube adenocarcinoma.

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