Associations and Combinations of Metabolic Parameters and ABCG2 rs2231142 Variant in Thai Men with Gout
DOI:
https://doi.org/10.31584/jhsmr.2023923%20Keywords:
ABCG2 rs2231142 variant, combinations, gout, men, metabolic parametersAbstract
Objective: This study aimed to investigate whether the risk of gout was associated with the ABCG2 rs2231142 variant and how this was affected by metabolic parameters.
Material and Methods: The subjects were selected from the genetic variations of urate transporter genes in hyperuricemia and gout in the Thai population (GUHGTH) study. Overall, 96 participants aged 30-60 years were included in the study. Adjusted odds ratio (AORs) of gout was analyzed using multiple logistic regression models and the effects of combinations of ABCG2 rs2231142 variants and metabolic parameters on gout were explored.
Results: The TG and TT genotypes of ABCG2 rs2231142 and hyperglycemia were significantly associated with gout risk. The risk of gout was significantly increased by the combined association of ABCG2 rs2231142 and metabolic parameters obesity and hyperglycemia for the TG and TT genotypes compared to the GG genotype (wild-type genotype).
Conclusion: In conclusion, the ABCG2 rs2231142 variant was found to be a genetic risk factor for gout in Thai men. Obesity and hyperglycemia combined with the ABCG2 rs2231142 risk allele contributed to an increase in the risk of gout. Further case-control studies with larger sample sizes should be performed to confirm the combinations of the ABCG2 rs2231142 variant, obesity, and hyperglycemia on the risk of gout.
References
Roddy E, Choi HK. Epidemiology of gout. Rheum Dis Clin North Am 2014;40:155-75.
Grassi W, De Angelis R. Clinical features of gout. Reumatismo 2012;63:238-45.
Wallace KL, Riedel AA, Joseph-Ridge N, Wortmann R. Increasing prevalence of gout and hyperuricemia over 10 years among older adults in a managed care population. J Rheumatol 2004;31:1582-7.
Kuo CF, Grainge MJ, Zhang W, Doherty M. Global epidemiology of gout: prevalence, incidence and risk factors. Nat Rev Rheumatol 2015;11:649-62.
Liu R, Han C, Wu D, Xia X, Gu J, Guan H, et al. Prevalence of hyperuricemia and gout in Mainland China from 2000 to 2014: a systematic review and meta-analysis. Biomed Res Int 2015;2015:762820.
Ragab G, Elshahaly M, Bardin T. Gout: an old disease in a new perspective - a review. J Adv Res 2017;8:495-511.
Akizuki S. A population study of hyperuricemia and gout in Japan--analysis of sex, age and occupational differences in thirty-four thousand people living in Nagano Prefecture. Ryumachi 1982;22:201-8.
Choi HK, Atkinson K, Karlson EW, Willett W, Curhan G. Purine-rich foods, dairy and protein intake, and the risk of gout in men. N Engl J Med 2004;350:1093-103.
Choi HK, Curhan G. Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study. BMJ 2008;336:309-12.
Bhole V, de Vera M, Rahman MM, Krishnan E, Choi H. Epidemiology of gout in women: fifty-two-year follow-up of a prospective cohort. Arthritis Rheum 2010;62:1069-76.
Cea Soriano L, Rothenbacher D, Choi HK, García Rodríguez LA. Contemporary epidemiology of gout in the UK general population. Arthritis Res Ther 2011;13:R39.
Rothenbacher D, Primatesta P, Ferreira A, Cea-Soriano L, Rodríguez LA. Frequency and risk factors of gout flares in a large population-based cohort of incident gout. Rheumatology (Oxford) 2011;50:973-81.
Facchini F, Chen YD, Hollenbeck CB, Reaven GM. Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration. JAMA 1991;266:3008-11.
Muscelli E, Natali A, Bianchi S, Bigazzi R, Galvan AQ, Sironi AM, et al. Effect of insulin on renal sodium and uric acid handling in essential hypertension. Am J Hypertens 1996;9:746-52.
Lippi G, Montagnana M, Luca Salvagno G, Targher G, Cesare Guidi G. Epidemiological association between uric acid concentration in plasma, lipoprotein(a), and the traditional lipid profile. Clin Cardiol 2010;33:E76-80.
Sarmah D, Sharma B. A correlative study of uric acid with lipid profile. Asian J Med Sci 2013;4:8-14.
Peng TC, Wang CC, Kao TW, Chan JY, Yang YH, Chang YW, et al. Relationship between hyperuricemia and lipid profiles in US adults. Biomed Res Int 2015;2015:127596.
Ali N, Rahman S, Islam S, Haque T, Molla NH, Sumon AH, et al. The relationship between serum uric acid and lipid profile in Bangladeshi adults. BMC Cardiovasc Disord 2019;19:42.
Hurba O, Mancikova A, Krylov V, Pavlikova M, Pavelka K, Stibůrková B. Complex analysis of urate transporters SLC2A9, SLC22A12 and functional characterization of non-synonymous allelic variants of GLUT9 in the Czech population: no evidence of an effect on hyperuricemia and gout. PLoS One 2014;9:e107902.
Dehghan A, Köttgen A, Yang Q, Hwang SJ, Kao WL, Rivadeneira F, et al. Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet 2008;372:1953-61.
Yang B, Mo Z, Wu C, Yang H, Yang X, He Y, et al. A genome wide association study identifies common variants influencing serum uric acid concentrations in a Chinese population. BMC Med Genomics 2014;7:10.
Yamagishi K, Tanigawa T, Kitamura A, Köttgen A, Folsom AR, Iso H. The rs2231142 variant of the ABCG2 gene is associated with uric acid levels and gout among Japanese people. Rheumatology (Oxford) 2010;49:1461-5.
Jiri M, Zhang L, Lan B, He N, Feng T, Liu K, et al. Genetic variation in the ABCG2 gene is associated with gout risk in the Chinese Han population. Clin Rheumatol 2016;35:159-63.
Hamajima N, Okada R, Kawai S, Hishida A, Morita E, Yin G, et al. Significant association of serum uric acid levels with SLC2A9 rs11722228 among a Japanese population. Mol Genet Metab 2011;103:378-82.
Chen CJ, Tseng CC, Yen JH, Chang JG, Chou WC, Chu HW, et al. ABCG2 contributes to the development of gout and hyperuricemia in a genome-wide association study. Sci Rep 2018;8:3137.
Köttgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, et al. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet 2013;45:145-54.
Okada Y, Sim X, Go MJ, Wu JY, Gu D, Takeuchi F, et al. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nat Genet 2012;44:904-9.
Lawrence JS. The epidemiology of chronic rheumatism. Ann Rheum Dis 1964;23:81-2.
Woodward OM, Köttgen A, Coresh J, Boerwinkle E, Guggino WB, Köttgen M. Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout. Proc Natl Acad Sci U S A 2009;106:10338-42.
Li R, Miao L, Qin L, Xiang Y, Zhang X, Peng H, et al. A meta analysis of the associations between the Q141K and Q126X ABCG2 gene variants and gout risk. Int J Clin Exp Pathol 2015;8:9812-23.
Wan W, Xu X, Zhao DB, Pang YF, Wang YX. Polymorphisms of uric transporter proteins in the pathogenesis of gout in a Chinese Han population. Genet Mol Res 2015;14:2546-50.
Zaidi F, Narang RK, Phipps-Green A, Gamble GG, Tausche AK, So A, et al. Systematic genetic analysis of early-onset gout: ABCG2 is the only associated locus. Rheumatology (Oxford) 2020;59:2544-9.
Zhang L, Spencer KL, Voruganti VS, Jorgensen NW, Fornage M, Best LG, et al. Association of functional polymorphism rs2231142 (Q141K) in the ABCG2 gene with serum uric acid and gout in 4 US populations: the PAGE Study. Am J Epidemiol 2013;177:923-32.
Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, Perola M, et al. Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet 2009;5:e1000504.
Wardhana W, Rudijanto A. Effect of uric acid on blood glucose levels. Acta Med Indones 2018;50:253-6.
Zhu Y, Hu Y, Huang T, Zhang Y, Li Z, Luo C, et al. High uric acid directly inhibits insulin signaling and induces insulin resistance. Biochem Biophys Res Commun 2014;447:707-14.
Xiong Q, Liu J, Xu Y. Effects of uric acid on diabetes mellitus and its chronic complications. Int J Endocrinol 2019;2019:9691345.
Salehidoost R, Aminorroaya A, Zare M, Amini M. Is uric acid an indicator of metabolic syndrome in the first-degree relatives of patients with type 2 diabetes? J Res Med Sci 2012;17:1005-10.
Sell H, Eckel J. Adipose tissue inflammation: novel insight into the role of macrophages and lymphocytes. Curr Opin Clin Nutr Metab Care 2010;13:366-70.
Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003;112:1796- 808.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
