Gender Dysphoria, Its Causes and Symptoms: A Review
DOI:
https://doi.org/10.31584/jhsmr.2022883Keywords:
causes, gender identity disorder, symptoms, treatmentAbstract
Gender dysphoria (GD) phenomenon is affected by a person’s instinct and identity.The aim of this present review study was to examine the causes, symptoms and treatment of GD. Various factors can be involved in the development of GD. And this disorder causes unpleasant physical, psychological and social complications for the individual. Therefore, therapeutic methods; such as, counseling, hormone therapy and transgender surgery can increase the mental health and quality of life for these individuals. The cause of GD can be attributed to a variety of biological, hormonal, psychological, social, family, and childhood abuse factors that are characterized by symptoms; such as, biological sex dissatisfaction, the desire to be the opposite sex, feelings and reactions of the opposite sex. These individuals are interested in transgender surgery with pharmaceutical surgical and other therapeutic methods to improve their quality of life.
References
Garg G, Elshimy G, Marwaha R. Gender dysphoria. Treasure Island (FL): StatPearls Publishing; 2022.
Mohammadi MR, Khaleghi A. Transsexualism: a different viewpoint to brain changes. Clin Psychopharmacol Neurosci 2018;16:136-43.
Reisner SL, Poteat T, Keatley J, Cabral M, Mothopeng T, Dunham E, et al. Global health burden and needs of transgender populations: a review. Lancet 2016;388:412-36.
Bouman WP, Claes L, Brewin N, Crawford JR, Millet N, Fernandez-Aranda F, et al. Transgender and anxiety: A comparative study between transgender people and the general population. Int J Transgend Health 2017;18:16-26.
Weyers S, Elaut E, De Sutter P, Gerris J,T’Sjoen G, Heylens G, etal.Long-term assessmentof thephysical, mental,andsexual health among transsexual women. J Sex Med 2009;6:752-60.
Cahill S, Makadon H. Sexual orientation and gender identity data collection in clinical settings and in electronic health records: a key toendinglgbthealthdisparities.LGBT Health2014;1:34-41.
Collin L, Reisner SL, Tangpricha V, Goodman M. Prevalence of transgender depends on the “case” definition: a systematic review. J Sex Med 2016;13:613-26.
Veale JF. Prevalence of transsexualism among New Zealand passport holders. Aust N Z J Psychiatry 2008;42:887-9.
Wiepjes CM, Nota NM, de Blok CJM, Klaver M, de Vries ALC, Wensing-Kruger SA, et al. The amsterdam cohort of gender dysphoria study (1972-2015): trends in prevalence, treatment, and regrets. J Sex Med 2018;15:582-90.
De Cuypere G, Van Hemelrijck M, Michel A, Carael B, Heylens G, Rubens R, et al. Prevalence and demography of transsexualism in Belgium. Eur Psychiatry 2007;22:137-41.
Jatchavala C, Udomratn P. Women and Gender, Diversity and Mental Health. In: Bährer-Kohler S, Bolea-Alamanac B,editors. Diversity in Global Mental Health. SpringerBriefs in Psychology. Cham: Springer; 2019;p.31-40.
Zucker KJ. Epidemiology of gender dysphoria and transgender identity. Sex Health 2017;14:404-11.
Mason A, Crowe E, Haragan B, Smith S, Kyriakou A. Gender dysphoria in young people: a model of chronic stress. Horm Res Paediatr 2021:340-51.
Aitken M, Steensma TD, Blanchard R, VanderLaan DP, Wood H, Fuentes A, et al. Evidence for an altered sex ratio in clinic-referred adolescents with gender dysphoria. J Sex Med 2015;12:756-63.
Taslim N, Canales AD, Alshehab SMT. Gender dysphoria: a medical and ethical perplexity as distinct from reality and the rational approach for muslim young people. Psychiatr Danub 2021;33:475-84.
Monstrey SJ, Ceulemans P, Hoebeke P, editors. Sex reassignment surgery inthefemale-to-maletranssexual. Semin Plast Surg 2011;25:229-44.
Swaab DF, Garcia-Falgueras A. Sexual differentiation of the human brain in relation to gender identity and sexual orientation. Funct Neurol 2009;24:17-28.
Bao AM, Swaab DF. Sexual differentiation of the human brain: relation to gender identity, sexual orientation and neuropsychiatricdisorders.Front Neuroendocrinol2011;32:214- 26.
van der Miesen AIR, Hurley H, Bal AM, de Vries ALC. Prevalence of the wish to be of the opposite gender in adolescents and adults with autism spectrum disorder. Arch Sex Behav 2018;47:2307-17. 20. Rajkumar RP. Gender identity disorder and schizophrenia: neurodevelopmental disorders with common causal mechanisms? Schizophr Res Treatment 2014;2014:463757.
Lee PA, Houk CP. Evaluation and management of children and adolescents with gender identification and transgender disorders. Curr Opin Pediatr 2013;25:521-7.
Berglund H, Lindström P, Dhejne-Helmy C, Savic I. Male to-female transsexuals show sex-atypical hypothalamus activation when smelling odorous steroids. Cerebral Cortex 2007;18:1900-8. 23. Iervolino AC, Hines M, Golombok SE, Rust J, Plomin R. Genetic andenvironmental influencesonsex-typedbehaviorduringthe preschool years. Child Dev 2005;76:826-40.
Saleem F, Rizvi SW. Transgender associations and possible etiology: a literature review. Cureus 2017;9:e1984.
Flegr J. Influence of latent toxoplasma infection on human personality, physiology and morphology: pros and cons of the Toxoplasma-human model in studying the manipulation hypothesis. J Exp Biol 2013;216:127-33.
Selten JP, Kahn RS. Schizophrenia after prenatal exposure to Toxoplasma gondii? Clin Infect Dis 2002;35:633-4.
Gooren L. The biology of human psychosexual differentiation. Horm Behav 2006;50:589-601.
Meyer-Bahlburg HF. From mental disorder to iatrogenic hypogonadism: dilemmas in conceptualizing gender identity variantsaspsychiatric conditions. Arch Sex Behav2010;39:461- 76. 29. Bejerot S, Humble MB, Gardner A. Endocrine disruptors, the increase of autism spectrum disorder and its comorbidity with gender identitydisorder-ahypotheticalassociation. Int J Androl 2011;34:e350.
Swaab D, Bao A. Sexual differentiation of the human brain: relation to gender identity, sexual orientation, and neuropsychiatricdisorders.Front Neuroendocrinol2011;32:214- 26.
Posar A, Resca F, Visconti P. Autism according to diagnostic and statistical manual of mental disorders 5th edition: the need for further improvements. J Pediatr Neurosci 2015;10:146-8.
Heylens G, Elaut E, Kreukels BP, Paap MC, Cerwenka S, Richter-Appelt H,etal. Psychiatric characteristics intranssexual individuals: multicentre study in four European countries. Br J Psychiatry 2014;204:151-6.
Mazaheri Meybodi A, Hajebi A, Ghanbari Jolfaei A. Psychiatric axis I comorbidities among patients with gender dysphoria. Psychiatry J 2014;971814.
Cooper K, Smith LGE, Russell AJ. Gender identity in autism: sex differences in social affiliation with gender groups. J Autism Dev Disord 2018;48:3995-4006
Bejerot S, Eriksson JM. Sexuality and gender role in autism spectrum disorder: a case control study. PLoS One 2014;9:e87961.
Skagerberg E, Di Ceglie D, Carmichael P. Brief report: autistic features in children and adolescents with gender dysphoria. J Autism Dev Disord 2015;45:2628-32.
Mendrek A. Reversal of normal cerebral sexual dimorphism in schizophrenia: evidence and speculations. Med Hypotheses 2007;69:896-902.
Putnam FW. Ten-year research update review: child sexual abuse. J Am Acad Child Adolesc Psychiatry 2003;42:269-78.
van Roode T, Dickson N, Herbison P, Paul C. Child sexual abuse and persistence of risky sexual behaviors and negative sexual outcomes over adulthood: findings from a birth cohort. Child Abuse Negl 2009;33:161-72.
Andrews G, Corry J, Slade T, Issakidis C, Swanston H. Child sexual abuse. Comparative quantification of health risks: global and regional burden of disease attributable to selected major risk factors. Geneva: World Health Organization2004:1851-940.
Fontanari AMV, Rovaris DL, Costa AB, Pasley A, Cupertino RB, Soll BMB, et al. Childhood maltreatment linked with a deterioration of psychosocial outcomes in adult life for southern brazilian transgender women. J Immigr Minor Health 2018;20:33-43.
Green JG, McLaughlin KA, Berglund PA, Gruber MJ, Sampson NA, Zaslavsky AM, et al. Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I: associations with first onset of DSM-IV disorders. Arch Gen Psychiatry 2010;67:113-23.
Schneeberger AR, Dietl MF, Muenzenmaier KH, Huber CG, Lang UE. Stressful childhood experiences and health outcomes in sexual minority populations: a systematic review. Soc Psychiatry Psychiatr Epidemiol 2014;49:1427-45.
Bandini E, Fisher AD, Ricca V, Ristori J, Meriggiola MC, Jannini EA, et al. Childhood maltreatment in subjects with male-to femalegender identitydisorder. Int J Impot Res2011;23:276-85.
Bowlby J. Attachment and loss: Volume II: Separation, anxiety and anger. London: The Hogarth Press and the Institute of Psycho-analysis; 1973.
Sroufe LA. Attachment and development: a prospective, longitudinal study from birth to adulthood. Attach Hum Dev 2005;7:349-67.
Glidden D, Bouman WP, Jones BA, Arcelus J. Gender dysphoria and autism spectrum disorder: a systematic review of the literature. Sex Med Rev 2016;4:3-14.
Giovanardi G, Vitelli R, Maggiora Vergano C, Fortunato A, Chianura L, Lingiardi V, et al. Attachment patterns and complex trauma in a sample of adults diagnosed with gender dysphoria. Front Psychol 2018;9:60.
Simon L, Zsolt U, Fogd D, Czobor P. Dysfunctional core beliefs, perceived parenting behavior and psychopathology in gender identity disorder: a comparison of male-to-female, female-to male transsexual and nontranssexual control subjects. J Behav Ther Exp Psychiatry 2011;42:38-45.
Cohen-Kettenis PT, Gooren LJ. Transsexualism: a review of etiology, diagnosis and treatment. J Psychosom Res 1999;46:315-33.
Sadock BJ. Kaplan & Sadock’s synopsis of psychiatry: behavioral sciences/clinical psychiatry. Philadelphia: Lippincott Williams & Wilkins; 2007.
Daniolos PT. Identity, conformity, and nonconformity: a closer look. J Am Acad Child Adolesc Psychiatry 2018;57:460-1.
Nieder TO, Herff M, Cerwenka S, Preuss WF, Cohen-Kettenis PT, De Cuypere G, et al. Age of onset and sexual orientation in transsexual males and females. J Sex Med 2011;8:783-91.
Lee MA. Emotional abuse in childhood and suicidality: the mediating roles of re-victimization and depressive symptoms in adulthood. Child Abuse Negl 2015;44:130-9.
Owen-Anderson AF, Bradley SJ,Zucker KJ. Expressedemotion in mothers of boys with gender identity disorder. J Sex Marital Ther 2010;36:327-45.
Alanko K, Santtila P, Harlaar N, Witting K, Varjonen M, Jern P, et al. The association between childhood gender atypical behavior and adult psychiatric symptoms is moderated by parenting style. Sex Roles 2008;58:837-47.
Judge C, O’Donovan C, Callaghan G, Gaoatswe G, O’Shea D. GD-prevalence and co-morbidities in an irish adult population. Front Endocrinol (Lausanne) 2014;5:87.
Khan SI, Hussain MI, Parveen S, Bhuiyan MI, Gourab G, Sarker GF, et al. Living on the extreme margin: social exclusion of the transgender population (hijra) in Bangladesh. J Health Popul Nutr 2009;27:441-51.
Katz-Wise SL, Rosario M, Tsappis M. Lesbian, gay, bisexual, and transgender youth and family acceptance. Pediatr Clin North Am 2016;63:1011-25.
Rosario M, Reisner SL, Corliss HL, Wypij D, Frazier AL, Austin SB. Disparities in depressive distress by sexual orientation in emerging adults: the roles of attachment and stress paradigms. Arch Sex Behav 2014;43:901-16.
Doyle DM, Begeny CT, Barreto M, Morton TA. Identity-related factors protect well-being against stigma for transgender and gender non-conforming people. Arch Sex Behav 2021;1:3191– 200.
Jatchavala C. Discourse and stigmatization of psychiatric disorder in Thailand. J Sociol Anthropol 2013;1:93-113.
Alastanos JN, Mullen S. Psychiatric admission in adolescent transgender patients: a case series. Ment Health Clin 2017;7:172-5.
Cohen-Kettenis PT, Pfafflin F. The DSM diagnostic criteria for gender identity disorder in adolescents and adults. Arch Sex Behav 2010;39:499-513.
Korasz K, SimonL. Diagnosisanddifferentialdiagnostic features of gender identity disorder. Psychiatr Hung 2008;23:196-205.
White Hughto JM, Reisner SL, Pachankis JE. Transgender stigma and health: a critical review of stigma determinants, mechanisms, andinterventions. Soc Sci Med2015;147:222-31.
Bockting WO, Miner MH, Swinburne Romine RE, Hamilton A, Coleman E. Stigma, mental health, and resilience in an online sample of the US transgender population. Am J Public Health 2013;103:943-51.
Meyer III W, Bockting WO, Cohen-Kettenis P, Coleman E, Diceglie D, Devor H,etal.The Harry Benjamininternational GD association’s standards of care for gender identity disorders, sixth version. J Psychol Human Sex 2002;13:1-30.
Sadocks BJ, Sadock V. Synopsis of psychiatry. Philadelphia: Lippincott Williams & Wilkins; 2007. 70. A.G. Sexual dysfunction. 12th ed. Tehran: Poetry mag; 2006.
Ohadi B. Human sexuality. 4th ed. Tehran: Sadegh Hedeya; 2006.
Segal DL. Diagnostic and statistical manual of mental disorders (DSM-IV-TR). In: Weiner IB, Craighead WE, editors. Corsini Encyclopedia Psychology. New York: John Wiley & Sons Inc.;2010:p.1-3.
Simons L, Schrager SM, Clark LF, Belzer M, Olson J. Parental support and mental health among transgender adolescents. J Adolesc Health 2013;53:791-3.
Coolhart D, Shipman DL. Working toward family attunement: family therapy with transgender and gender-nonconforming childrenandadolescents. Psychiatr Clin North Am 2017;40:113- 25.
Costa R, Colizzi M.Theeffectof cross-sexhormonal treatment on gender dysphoria individuals’ mental health: a systematic review. Neuropsychiatr Dis Treat 2016;12:1953-66.
Broad KL. Coming out for parents, families and friends of lesbians and gays: From support group grieving to love advocacy. Sexualities 2011;14:399-415.
Menvielle E, Hill DB. An affirmative intervention for families with gender-variant children: a process evaluation. J Gay Lesbian Ment Health 2010;15:94-123.
Menvielle EJ, Tuerk C. A support group for parents of gender nonconforming boys. J Am Acad Child Adolesc Psychiatry 2002;41:1010-3.
Nelson T, Winawer H. Critical topics in family therapy: AFTA monograph series highlights. In: Nelson T, Winawer H. editors. AFTA SpringerBriefs inFamilyTherapy. Cham: Springer; 2014; p.1-4.
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