Characteristics of the Wells Score and Associated Factors of Pulmonary Embolisms in Inpatients with Deep Venous Thrombosis

Authors

  • Sarayuth Boonchai Division of Urology, Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
  • Osaree Akaraborworn Division of Trauma and Critical Care, Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.

DOI:

https://doi.org/10.31584/jhsmr.2021851

Keywords:

deep vein thrombosis, pulmonary embolism, venous thromboembolism

Abstract

Objective: To evaluate the characteristics of the Wells score and associated factors of acute pulmonary embolisms (PE) in surgical-based inpatients’ with acute deep venous thrombosis (DVT), at Songklanagarind Hospital.

Material and Methods: Acute DVT inpatients in the departments of surgery, obstetrics-gynecology and orthopedics; from 2010 to 2016, were extracted from medical records, and retrospectively reviewed. The Wells score was calculated for risk stratification in terms of low, moderate, and high probability. Finally, the associated factors of acute PE were assessed.

Results: There were 278 inpatients diagnosed with acute DVT in the surgery (n=142), obstetrics-gynecology (n=101, and orthopedics (n=35) wards. The numbers of low, moderate and high risk probability were 4 (1.0%), 141 (51.0%) and 133 (48.0%), respectively. We identified four factors that were significantly different between the three specialties comprising of: “paralysis, paresis, or recent plaster immobilization of the lower extremities”, “recently bedridden or underwent a major surgical procedure”, “leg edema” and “active cancer”. Regarding the surgery service, patients with acute PE experienced a higher rate of bilateral DVT than those who did not—28.0% and 8.0%, respectively.

Conclusion: The low-risk probability determined by Wells score had low incidence of acute DVT in in-patient department settings. Acute bilateral DVT was more significantly associated with acute PE in the surgery service.

References

Beckman MG, Hooper WC, Critchley SE, Ortel TL. Venous thromboembolism: a public health concern. Am J Prev Med 2010;38(4 Suppl):S495–501.

Galanaud JP, Sevestre-Pietri MA, Bosson JL, Laroche JP, Righini M, Brisot D, et al. Comparative study on risk factors and early outcome of symptomatic distal versus proximal deep vein thrombosis: results from the OPTIMEV study. Thromb Haemost 2009;102:493–500.

Wells PS, Anderson DR, Bormanis J, Guy F, Mitchell M, Gray L, et al. Value of assessment of pretest probability of deep-vein thrombosis in clinical management. Lancet 1997;350:1795–8.

Wells PS, Anderson DR, Rodger M, Forgie M, Kearon C, Dreyer J, et al. Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. N Engl J Med 2003;349: 1227–35.

Subramaniam RM, Snyder B, Heath R, Tawse F, Sleigh J. Diagnosis of lower limb deep venous thrombosis in emergency department patients: performance of Hamilton and modified Wells scores. Ann Emerg Med 2006;48:678–85.

Lustig DB, Rodriguez R, Wells PS. Implementation and validation of a risk stratification method at The Ottawa Hospital to guide thromboprophylaxis in ambulatory cancer patients at intermediate-high risk for venous thrombosis. Thromb Res 2015; 136:1099–102.

Dronkers CEA, Tan M, Mol GC, Iglesias Del Sol A, van de Ree MA, Huisman MV, et al. Evaluation of the new simple and objective clinical decision rule “I-DVT” in patients with clinically suspected acute deep vein thrombosis. Thromb Res 2016;141: 112–8.

Gaitini D, Khoury R, Israelit S, Beck-Razi N. Sparing ultrasound in emergency department patients with suspected deep vein thrombosis by using clinical scores and D-dimer testing. J Clin Ultrasound 2016;44:231–9.

Engelberger RP, Aujesky D, Calanca L, Staeger P, Hugli O, Mazzolai L. Comparison of the diagnostic performance of the original and modified Wells score in inpatients and outpatients with suspected deep vein thrombosis. Thromb Res 2011;127: 535–9.

Geersing GJ, Zuithoff NPA, Kearon C, Anderson DR, Ten Cate-Hoek AJ, Elf JL, et al. Exclusion of deep vein thrombosis using the Wells rule in clinically important subgroups: individual patient data meta-analysis. BMJ 2014;348: g1340.

Modi S, Deisler R, Gozel K, Reicks P, Irwin E, Brunsvold M, et al. Wells criteria for DVT is a reliable clinical tool to assess the risk of deep venous thrombosis in trauma patients. World J Emerg Surg 2016;11:24.

Silveira PC, Ip IK, Goldhaber SZ, Piazza G, Benson CB, Khorasani R. Performance of Wells score for deep vein thrombosis in the inpatient setting. JAMA Intern Med 2015; 175:1112–7.

Bastos M de, Barreto SM, Caiafa JS, Rezende SM. Thromboprophylaxis: medical recommendations and hospital programs. Rev Assoc Med Bras (1992) 2011;57:88–99.

Collins R, Scrimgeour A, Yusuf S, Peto R. Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin. Overview of results of randomized trials in general, orthopedic, and urologic surgery. N Engl J Med 1988;318:1162–73.

Wayne WD. Biostatistics: a foundation of analysis in the health sciences. 6th ed. New York: Wiley & Sons; 1995.

Ngamjarus C, Chongsuvivatwong V. n4Studies: sample size and power calculations for android. Bangkok: The Royal Golden Jubilee Ph.D. Program, The Thailand Research Fund & Prince of Songkla University; 2014.

Girard P, Decousus M, Laporte S, Buchmuller A, Herve P, Lamer C, et al. Diagnosis of pulmonary embolism in patients with proximal deep vein thrombosis: specificity of symptoms and perfusion defects at baseline and during anticoagulant therapy. Am J Respir Crit Care Med 2001;164:1033–7.

Sullivan LT 2nd, Jackson LR 2nd, Thomas KL. Review of venous thromboembolism and race: the generalizability of treatment guidelines for high-risk populations. J Thromb Thrombolysis 2016;42:167–71.

Huang SS, Liu Y, Jing ZC, Wang XJ, Mao YM. Common genetic risk factors of venous thromboembolism in Western and Asian populations. Genet Mol Res 2016;15:15017644.

Feng JP, Xiong YT, Fan ZQ, Yan LJ, Wang JY, Gu ZJ. Efficacy of intermittent pneumatic compression for venous thromboembolism prophylaxis in patients undergoing gynecologic surgery: a systematic review and meta-analysis. Oncotarget 2017;8:20371–9.

Kakkos SK, Caprini JA, Geroulakos G, Nicolaides AN, Stansby G, Reddy DJ, et al. Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism. Cochrane Database Syst Rev 2016;9:CD005258.

BMJ Best Practice. Deep vein thrombosis – approach [homepage on the Internet]. London: BMJ Best Practice [cited 2018 Mar 17]. Available from: http://bestpractice.bmj.com/topics/en-gb/ 70/diagnosis-approach

Streiff MB, Agnelli G, Connors JM, Crowther M, Eichinger S, Lopes R, et al. Guidance for the treatment of deep vein thrombosis and pulmonary embolism. J Thromb Thrombolysis 2016;41:32– 67.

Hill J, Treasure T. Reducing the risk of venous thromboembolism (deep vein thrombosis and pulmonary embolism) in inpatients having surgery: summary of NICE guidance. BMJ 2007;334: 1053–4.

Kearon C, Akl EA, Ornelas J, Blaivas A, Jimenez D, Bounameaux H, et al. Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report. Chest 2016;149: 315–52.

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Published

2022-07-22

How to Cite

1.
Boonchai S, Akaraborworn O. Characteristics of the Wells Score and Associated Factors of Pulmonary Embolisms in Inpatients with Deep Venous Thrombosis. J Health Sci Med Res [Internet]. 2022 Jul. 22 [cited 2024 Dec. 23];40(4):411-8. Available from: https://he01.tci-thaijo.org/index.php/jhsmr/article/view/257751

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