Long-term Efficacy of Q-switched 1064 nm Nd-YAG Laser for Treatment of Split-thickness Skin Graft: A Randomized Controlled Trial

Authors

  • Atthawit Mongkornwong Division of Plastic and Reconstructive Surgery, Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
  • Warangkana Tonaree Division of Plastic and Reconstructive Surgery, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkoknoi, Bangkok 10700, Thailand.
  • Apirag Chuangsuwanich Division of Plastic and Reconstructive Surgery, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkoknoi, Bangkok 10700, Thailand.
  • Sitthichoke Taweepraditpol Division of Plastic and Reconstructive Surgery, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkoknoi, Bangkok 10700, Thailand.

DOI:

https://doi.org/10.31584/jhsmr.2021840

Keywords:

long-term efficacy, Q-switched 1064 nm Nd-YAG laser, split-thickness skin graft, treatment

Abstract

Objective: The aim of this study was to investigate the efficacy of the Q-switched 1064 nm Nd:YAG laser for reducing hyperpigmentation and erythema and increasing pliability in skin grafts.

Material and Methods: This was a prospective randomized controlled trial. Half of each skin graft was treated with a Q-switched 1064 nm Nd:YAG laser 4 times, and the other half was left untreated and collectively used as the controls. The treatment results were evaluated by clinical photographs, and assessment of the melanin index (MI), erythema index (EI), and elasticity parameters at baseline and at 2 weeks after each session and 1 month after the final treatment.

Results: Ten skin graft sites from 10 patients were included. Most patients had lesions at a lower extremity. After 4 sessions of treatment, average melanin index at the treated sites was non-significantly decreased compared to both baseline (p-value=0.232) and the untreated sites (p-value=0.770). The elasticity of the treated sites increased significantly when compared to baseline (p-value=0.039), but non-significantly when compared to the untreated sites (p-value=0.846). The EI at the treated sites non-significantly decreased compared to both baseline (p-value=0.432) and the untreated sites (p-value=0.164).

Conclusion: This study found the Q-switched 1064 nm Nd:YAG laser treatment to be a potentially promising modality for increasing the pliability of skin grafts, but reductions in hyperpigmentation and erythema were only clinically significant.

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Published

2021-09-20

How to Cite

1.
Mongkornwong A, Tonaree W, Chuangsuwanich A, Taweepraditpol S. Long-term Efficacy of Q-switched 1064 nm Nd-YAG Laser for Treatment of Split-thickness Skin Graft: A Randomized Controlled Trial. J Health Sci Med Res [Internet]. 2021 Sep. 20 [cited 2022 Jun. 26];40(3):309-16. Available from: https://he01.tci-thaijo.org/index.php/jhsmr/article/view/255391

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