Spurious Hyperphosphatemia in a Patient with Multiple Myeloma: A Case Report
DOI:
https://doi.org/10.31584/jhsmr.2021790Keywords:
hyperphosphatemia, multiple myeloma, paraprotein, pseudohyperphosphatemia, spuriousAbstract
Spurious hyperphosphatemia has been reported periodically in multiple myeloma (MM) patients with paraproteinemia. It is important for clinicians to recognize this phenomenon in order to avoid misdiagnosis and unnecessary treatment for true hyperphosphatemia. This case report demonstrates a case of spurious hyperphosphatemia in an MM patient whose serum phosphate could be normalized by deproteinization of a blood sample, a simple and widely available correction technique.
References
Atchison DK, Humes HD. A case of tumor lysis syndrome and acute renal failure associated with elotuzumab treatment in multiple myeloma. Clin Nephrol Case Stud 2017;5:78–81.
Leehey DJ, Daugirdas JT, Reid RW. Spurious hyperphosphatemia due to hyperlipidemia. Arch Intern Med 1985; 145:743-4.
Khan TA, Arif A, Seamonds B, Doyle AM. Spurious hyperphosphatemia related to severe hyperbilirubinemia in patients with end-stage liver disease. Clin Nephrol 2014;82:368–71.
Talebi S, Gomez N, Iqbal Z, Pekler G, Visco F, Hassen GW, et al. Spurious hyperphosphatemia: a diagnostic and therapeutic challenge. Am J Med 2016;129:e15–6.
Bakker AJ, Bosma H, Christen PJ. Influence of monoclonal immunoglobulins in three different methods for inorganic phosphorus. Ann Clin Biochem 1990;27:227–31.
Stratta P, Canavese C, Quaglia M, Lazzarich E, Morellini V, Brustia M, et al. A patient with unexplained hyperphosphataemia. Nephrol Dial Transplantation 2006;21:2664–6.
Lee Y, Koo T, Yi JH, Choi JH, Han SW, Park IK, et al. Pseudohyperphosphatemia in a patient with multiple myeloma. Electrolyte Blood Press 2007;5:131.
Lovekar S, Chen JLT. A 90-year-old man with hyperphosphatemia. Am J Kidney Dis 2011;57:342–6.
Busse JC, Gelbard MA, Byrnes JJ, Hellman R, Vaamonde CA. Pseudohyperphosphatemia and dysproteinemia. Arch Intern Med 1987;147:2045–6.
Chakraborty S, Sen S, Gupta D, Ghosh SS, Sawant P, Das M. Spurious hyperphosphatemia in a case of multiple myeloma. Ind J Clin Biochem 2014;29:250–2.
Mandry M, Posner MR, Tucci JR, Eil C. Hyperphosphatemia in multiple myeloma due to a phosphate-binding immunoglobulin. Cancer 1991;68:1092-4.
Sonnenblick M, Eylath U, Brisk R, Eldad C, Hershko C. Paraprotein interference with colorimetry of phosphate in serum of some patients with multiple myeloma. Clin Chem 1986;32: 1537–9.
Craddock N, Craddock B. Psychiatric discharge summaries: differing requirements of psychiatrists and general practitioners. BMJ 1989;299:1382.
Pantanowitz L, Horowitz GL, Upalakalin JN, Beckwith BA. Artifactual hyperbilirubinemia due to paraprotein interference. Arch Pathol Lab Med 2003;127:5.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.