Blood Cholesterol Levels of Family Members of Stroke Patients in Suburban Areas
DOI:
https://doi.org/10.31584/jhsmr.2021782Keywords:
cholesterol level, dyslipidemia, family members of strokeAbstract
Objective: (1) To study dyslipidemia prevalence of members in stroke patients’ families (2) To investigate factors related to dyslipidemia of members in stroke patients’ families
Material and Methods: In this cross-sectional analytical study, after patients suffered from a stroke, the subjects were visited, interviewed through a questionnaire, and blood was drawn for testing, without fasting. This was in order to establish their cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and random plasma glucose. This also included a physical checkup and risk assessment for cardiovascular disease. The data were collected from 120 subjects.
Results: Prevalence of high total cholesterol level was 34.2%, low HDL-C was 15.8%, high LDL-C level was 37.5%, and prevalence of dyslipidemia was 51.7%. The samples were 76 blood relatives and 44 non-blood relatives in the patients’ families. The average LDL-C level was 147.12+39.06 and 31.7% of them suffered from Class 1 obesity, and 15.8% of them faced Class 2 obesity. According to Thai CV risk scores, the results revealed that 80.8% of the samples had a low risk, at <10.0%. The factors related to dyslipidemia were underlying diseases, and most groups of underlying diseases were hypertension and diabetes mellitus, respectively.
Conclusion: Prevalence of dyslipidemia in family Members of Stroke Patients was 51.7%. Detection of this abnormality is important to them. This would help in designing a prevention plan, as well as to raise awareness of stroke prevention in family members of stroke patients.
References
Papol A, Boonkaew N. Comparison of stroke risk assessment tools. EAU Heritage J 2018;12:62-70.
Saicamthon P, Tipsriraj S, Chaisaen K, Yingyong T, Sugawong K. The effect of risk factors for cerebrovascular disease, regional health 1, Thailand. Lanna Public Health J 2016;12: 44-5.
Lindsay P, Furie KL, Davis SM, Donnan GA, Norrving B. World stroke organization global stroke services guidelines and action plan. J Stroke 2014;9:4-13.
Watkins LO. Epidemiology and burden of cardiovascular disease. Clin Cardiol 2004;27(Suppl 3):III2-6. 5. Gordon DJ, Probstfield JL, Garrison RJ, Neaton JD, Castelli WP. High-density lipoprotein cholesterol cardiovascular disease. Four prospective American studies. Circulation 1989; 79:8–15.
Verschuren WM, Boerma GJ, Kromhout D. Total and HDLcholesterol in The Netherlands: 1987–1992. Levels and changes over time in relation to age, gender and educational level. Int J Epidemiol 1994;23:948–56.
Assmann G, Schulte H, von Eckardstein A, Huang Y. Highdensity lipoprotein cholesterol as a predictor of coronary heart disease risk. The PROCAM experience and pathophysiological implications for reverse cholesterol transport. Atherosclerosis 1996;124(Suppl):11–20.
Goldbourt U, Yaari S, Medalie JH. Isolated low HDL cholesterol as a risk factor for coronary heart disease mortality. A 21-year follow-up of 8000 men. ATVB 1997;17:107–13.
Eastern Stroke Coronary Heart Disease Collaborative Research Group. Blood pressure, cholesterol, and stroke in eastern Asia. Lancet 1998;352:1801–7.
Stamler J, Daviglus ML, Garside DB, Dyer AR, Greenland P. Relationship of baseline serum cholesterol levels in 3 large cohorts of younger men to long-term coronary, cardiovascular, and all-cause mortality and to longevity. JAMA 2000;284: 311–8.
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA 2001;285:2486-97.
Bhuripanyo K, Tatsanavivat P, Matrakool B, Muktabhant B, Bhuripanyo P, Harnthaveesompol S. A prevalence survey of lipids abnormalities of rural area in Amphoe Phon, Khon Kaen. J Med Assoc Thai 1993;76:101-8.
Lindenstrom E, Boysen G, Nyboe J. Influence of total cholesterol, high density lipoprotein cholesterol, and triglycerides on risk of cerebrovascular disease: the Copenhagen City Heart Study. BMJ 1994;309:11–5.
Chaisiri K, Pongpaew P, Tungtrongchitr R, Phonrat B, Kulleap S, Sutthiwong P, et al. Nutritional status and serum lipids of a rural population in Northeast Thailand-an example of health transition. Int J Vitam Nutr Res 1998;68:196-202.
Stamler J, Daviglus ML, Garside DB, Dyer AR, Greenland P, Neaton JD. Relationship of baseline serum cholesterol levels in 3 large cohorts of younger men to long-term coronary, cardiovascular, and all-cause mortality and to longevity. JAMA 2000;284:311–8. 16. Yamwong P, Assantachai P, Amornrat A. Prevalence of dyslipidemia in the elderly in rural areas of Thailand. Southeast Asian J Trop Med Public Health 2000;31:158-62
Yusuf S, Reddy S, Ounpuu S, Anand S. Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation 2001;104:2746–53.
Pongchaiyakul C, Pongchaiyakul C, Pratipanawatr T. Prevalence of dyslipidemia in rural Thai adults: an epidemiologic study in Khon Kaen province. J Med Assoc Thai 2005;88:1092-7.
Marshall J. Familial incidence of cerebral hemorrhage. Stroke 1973;4:38-41.
Khaw Kay-T, Barrett-Connor E. Family history of stroke as an independent predictor of ischemic heart disease in men and stroke in women. Am J Epidemiol 1986;123:59-66.
Howard G, Evans G, Toole JF, Tell J, Rose L, Espeland M, et al. Characteristics of stroke victims associated with early cardiovascular mortality in their children. J Clin Epidemiol 1990;43:49-54.
Brass LM, Shaker LA. Family history in patients with transient ischemic attacks. Stroke 1991;22:837-41.
Graffagnino C, Gasecki AP, Doig GS, Hachinski VC. The importance of family history in cerebrovascular disease. Stroke 1994;25:1599-604.
World Health Organization. The Asia-Pacific perspective redefining obesity and its treatment [monograph on the Internet]. Geneva: WHO; 2000 [cited 2019 Jun 11]. Available from: https://apps.who.int/iris/bitstream/handle/10665/ 206936/0957708211_eng.pdf?sequence=1&isAllowed=y
Roche Diagnostics GmbH. Cholesterol CHOD-PAP method. Mannheim: Roche Diagnostics GmbH; 2000.
Roche Diagnostics GmbH. HDL-Cholesterol and LDLCholesterol plus. Mannheim: Roche Diagnostics GmbH; 2000.
Michael SL, Phil BF. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;285:2486-97.
O’Brien E, Petrie J, Littler W, de Swiet M, Padfield PL, O’Malley K, et al. The British Hypertension Society protocol for the evaluation of automated and semi-automated blood pressure measuring devices with special reference to ambulatory systems. J Hypertens 1990;8:607-19.
Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, et al. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 Report. JAMA 2003;289: 2560-72.
World Health Organization. Physical activity [homepage on the Internet]. Geneva: WHO; 2015 [cited 2018 Feb 23]. Available from: https://www.who.int/en/news-room/fact-sheets/detail/ physical-activity
Bhuripanyo K, mahanonda N, Leowattana W, Ruangratanaamporn O, Sriratanasathavorn C, Chotinaiwattarakul C, et al. A 5-year prospective study of conventional risk factors of coronary artery disease in Shinawatra employees: a preliminary prevalence survey of 3,615 employees. J Med Assoc Thai 2000;83(Suppl 2):S98-105.
Yamwong P, Assantachai P, Amornrat A. Prevalence of dyslipidemia in the elderly in rural areas of Thailand. Southeast Asian J Trop Med Public Health 2000;31:158-62.
Wichai A, Surasak T, Pattapong K, Virasakdi C, Panwadee P, Piyamitr S, et al. Prevalence of dyslipidemia and management in the Thai Population, National Health Examination Survey IV, 2009 [monograph on the Internet]. London: Hindawi; 2014 [cited 2020 Jun 11]. Available from: http://downloads.hindawi. com/journals/jl/2014/249584.pdf
Suchat H, Niphon P, Samart N, Nijasri S, Pimchanok P, Somchai T, et al. Prevalence of stroke and stroke risk factors in Thailand: Thai Epidemiologic Stroke (TES) study. J Med Assoc Thai 2011; 94:427-36.
Choowong P, Chatlert P, Thongchai P. Prevalence of dyslipidemia in rural Thai adults: an epidemiologic study in Khon Kaen Province. J Med Assoc Thai 2005;88:1089-9.
Pornpimon C, Benja M, Frank PS. Prevalence and factors associated with non-high density lipoprotein cholesterol among Thai adults in Khon Kaen Province of Northeastern Thailand. J Public Health Development 2017;15:49-61.
Bhuripanyo K, Tatsanavivat P, Matrakool B, Muktabhant B, Bhuripanyo P, Harnthaveesompol S. A prevalence survey of lipids abnormalities of rural area in Amphoe Phon, Khon Kaen. J Med Assoc Thai 1993;76:101-8.
Chaisiri K, Pongpaew P, Tungtrongchitr R, Phonrat B, Kulleap S, Sutthiwong P, et al. Nutritional status and serum lipids of a rural population in Northeast Thailand-an example of health transition. Int J Vitam Nutr Res 1998;68:196-202.
Pongchaiyakul C, Hongsprabhas P, Pisprasert V. Rural-urban difference in lipid levels and prevalence of dyslipidemia: a population-based study in Khon Kaen province, Thailand. J Med Assoc Thai 2006;89:1835-44.
Iyad A, Mahmoud A, Anan A, Omar S, Ahmad AS, Sabreen M, et al. The prevalence of dyslipidemia and hyperglycemia among stroke patients: preliminary findings [homepage on the Internet]. London: Hindawi; 2015 [cited 2020 Jan 20]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875342/ pdf/SRT2019-8194960.pdf
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.