Concomitant Hyperparathyroidism Due to Occult Parathyroid Adenoma Detected by Technetium-99m Sestamibi Single-photon Computed Tomography/Computerized Tomography in a Patient with Papillary Thyroid Carcinoma

Authors

  • Jiraporn Sriprapaporn Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok Noi, Bangkok 10700, Thailand
  • Pongthep Pisarnturakit Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok Noi, Bangkok 10700, Thailand
  • Tauangtham Anekpuritanang Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok Noi, Bangkok 10700, Thailand

DOI:

https://doi.org/10.31584/jhsmr.2020751

Keywords:

Hyperparathyroidism, parathyroid adenoma, parathyroid scintigraphy, SPECT/CT, thyroid cancer

Abstract

Although the occurrence of thyroid and parathyroid diseases is common, concomitant parathyroid adenoma and papillary thyroid carcinoma is rare. We report the case of a 77-year-old Thai woman who was diagnosed to have papillary thyroid carcinoma and postoperative hypercalcemia. The primary hyperparathyroidism was initially overlooked but was subsequently confirmed to be due to a single occult parathyroid adenoma demonstrated on technetium99m sestamibi (Tc-99m MIBI) parathyroid scintigraphy. Thus, preoperative evaluation of parathyroid disease should be performed if there is evidence of hypercalcemia prior to the thyroid surgery. Presurgical evaluation with Tc-99m MIBI parathyroid single-photon computed tomography/computerized tomography imaging has a definite role in localizing a hyperfunctioning parathyroid gland in the cases of primary hyperparathyroidism.

References

Rao SD. Epidemiology of parathyroid disorders. Best Pract Res Clin Endocrinol Metab 2018;32:773-80.

Cordellat IM. Hyperparathyroidism: primary or secondary disease? Rheumatol Clin 2012;8:287-91.

Gopinath P, Mihai R. Hyperparathyroidism. Surgery 2011;29: 451-8.

Shindo M, Lee JA, Lubitz CC, McCoy KL, Orloff LA, Tufano RP, et al. The changing landscape of primary, secondary, and tertiary hyperparathyroidism: highlights from the American College of Surgeons panel, “What's new for the surgeon caring for patients with hyperparathyroidism?”. J Am Coll Surg 2016; 222:1240-50.

Madkhali T, Alhefdhi A, Chen H, Elfenbein D. Primary hyperparathyroidism. Ulus Cerrahi Derg 2016;32:58-66.

Jovanovic MD, Zivaljevic VR, Diklic AD, Rovcanin BR, V Zoric G, Paunovic IR. Surgical treatment of concomitant thyroid and parathyroid disorders: analysis of 4882 cases. Eur Arch Otorhinolaryngol 2017;274:997-1004.

Bentrem DJ, Angelos P, Talamonti MS, Nayar R. Is preoperative investigation of the thyroid justified in patients undergoing parathyroidectomy for hyperparathyroidism? Thyroid 2002; 12:1109-12.

Wright MC, Jensen K, Mohamed H, Drake C, Mohsin K, Monlezun D, et al. Concomitant thyroid disease and primary hyperparathyroidism in patients undergoing parathyroidectomy or thyroidectomy. Gland Surg 2017;6:368-74.

Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 2016;26:1-133.

Ghorra C, Rizk H, Abi Hachem R, Tannoury J, Abboud B. Association of parathyroid pathology with well-differentiated thyroid carcinoma. Presse Med 2012;41:e265-71.

Rosen IB, Strawbridge HG, Bain J. A case of hyperparathyroidism associated with radiation to the head and neck area. Cancer 1975;36:1111-4.

Colaço SM, Si M, Reiff E, Clark OH. Hyperparathyroidism after radioactive iodine therapy. Am J Surg 2007;194:323-7.

Cadena-Piñeros E, De Los Reyes CA, Llamas-Olier A, Romero-Rojas AE. Advantages of the (99m)Tc-sestamibi Single-Photon Emission Computed Tomography/Computed Tomography in Occult Parathyroid Adenoma and Concomitant Thyroid Papillary Carcinoma. Indian J Nucl Med 2019;34:150-2.

Taywade SK, Damle NA, Tripathi M, Agarwal S, Aggarwal S. Synchronous parathyroid adenoma and papillary thyroid cancer detected on 99mTc-sestamibi scintigraphy. Indian J Endocrinol Metab 2016;20:878–9.

Wei WJ, Shen CT, Song HJ, Qiu ZL, Luo QY. Comparison of SPET/CT, SPET and planar imaging using 99mTc-MIBI as independent techniques to support minimally invasive parathyroidectomy in primary hyperparathyroidism: a metaanalysis. Hell J Nucl Med 2015;18:127-35.

Norton KS, Johnson LW, Griffen FD, Burke J, Kennedy S, Aultman D, et al. The sestamibi scan as a preoperative screening tool. Am Surg 2002;68:812-5.

Efstratios Moralidis. Radionuclide parathyroid imaging: a concise, updated review Hell J Nucl Med 2013;16:125-33.

Calva-Cerqueira D, Smith BJ, Hostetler ML, Lal G, Menda Y, O'Dorisio TM, et al. Minimally invasive parathyroidectomy and preoperative MIBI scans: correlation of gland weight and preoperative PTH. J Am Coll Surg 2007;205(Suppl 4):S38- 44.

Kim YI, Jung YH, Hwang KT, Lee HY. Efficacy of ⁹⁹mTcsestamibi SPECT/CT for minimally invasive parathyroidectomy: comparative study with ⁹⁹mTc-sestamibi scintigraphy, SPECT, US and CT. Ann Nucl Med 2012;26:804-10.

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Published

2020-07-03

How to Cite

1.
Sriprapaporn J, Pisarnturakit P, Anekpuritanang T. Concomitant Hyperparathyroidism Due to Occult Parathyroid Adenoma Detected by Technetium-99m Sestamibi Single-photon Computed Tomography/Computerized Tomography in a Patient with Papillary Thyroid Carcinoma. J Health Sci Med Res [Internet]. 2020 Jul. 3 [cited 2024 Nov. 22];38(4):337-42. Available from: https://he01.tci-thaijo.org/index.php/jhsmr/article/view/244617

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Section

Case Report