P-cadherin and CD10 Expression to Distinguish between Ductal Carcinoma in Situ and Invasive Ductal Carcinoma of the Breast

Authors

  • Kanet Kanjanapradit Department of Pathology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
  • Sittipong Wangsawibul Institute of Pathology, Ratchathewi, Bangkok 10400, Thailand.

DOI:

https://doi.org/10.31584/jhsmr.201936

Keywords:

CD10, ductal carcinoma in situ, invasive ductal carcinoma, myoepithelial cell, P-cadherin

Abstract

Objective: To use placental cadherin (P-cadherin) and cluster of differentiation 10 (CD10) immunohisto chemical staining, to separate ductal carcinoma in situ (DCIS) from invasive ductal carcinoma (IDC).
Material and Methods: DCIS (n=48), equivocal (n=18), and IDC grade 1 (n=17) cases were evaluated by using immunohisto chemical staining, with P-cadherin and CD10 for identifying the myoepithelial cells.
Results: P-cadherin is positive in myoepithelial cells in almost all cases of DCIS (79.0%), and equivocal groups (61.0%). CD10 also shows a positive result in most cases of DCIS (98.0%) along with equivocal groups (72.0%). Both, P-cadherin and CD10 are negative in all cases of IDC grade 1. P-cadherin shows a high percentage of positivity in luminal cell in DCIS (83.0%), equivocal group (100.0%) and IDC grade 1 (88.0%). CD10 shows a low positive in the luminal cell of most cases of DCIS (13.0%), equivocal group (6.0%) and IDC grade 1 (0.0%). CD10 is positive in myofibroblastic cells in approximately 30.0% of all cases, but P-cadherin shows all negative staining.
Conclusion: P-cadherin and CD10 show high sensitivity for detecting the myoepithelial cells, but P-cadherin has a lower specificity, due to it having more luminal cells expression. Therefore, P-cadherin may be helpful for diagnosis in some cases that have a high expression of CD10 in myofibroblastic cells.

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Published

2019-01-03

How to Cite

1.
Kanjanapradit K, Wangsawibul S. P-cadherin and CD10 Expression to Distinguish between Ductal Carcinoma in Situ and Invasive Ductal Carcinoma of the Breast. J Health Sci Med Res [Internet]. 2019 Jan. 3 [cited 2022 Oct. 1];37(1):35-42. Available from: https://he01.tci-thaijo.org/index.php/jhsmr/article/view/140625

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