The relationship between metabolite from 1H-MRS and brain volume by magnetic resonance technique in methamphetamine users

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Published: Sep 3, 2017
Keywords:
Methamphetamine magnetic resonance spectroscopy brain volumes

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Nuttawadee Intachai
Department of Radiological Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai Province, Thailand
Artit Rodkong
Department of Radiological Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai Province, Thailand
Napapon Sailasuta
Huntington Medical Research Institute, California, USA
Apinun Aramrattana
Department of Family Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai Province, Thailand
Kanok Uttawichai
Thanyarak Hospital, Chiang Mai Province, Thailand
Mekkla Thompson
Westat Inc., Maryland, USA
Bangorn Sirirojn
Research Institute for Health Sciences, Chiang Mai University, Chiang Mai Province, Thailand
Daralak Thavornprasit
Research Institute for Health Sciences, Chiang Mai University, Chiang Mai Province, Thailand
Sineenart Taejaroenkul
Research Institute for Health Sciences, Chiang Mai University, Chiang Mai Province, Thailand
Kamolrawee sintupat
Research Institute for Health Sciences, Chiang Mai University, Chiang Mai Province, Thailand
Victor Valcour
Department of Neurology, University of California San Francisco, California, USA
Robert Paul
Department of Psychological Sciences, University of Missouri-St. Louis, Missouri, USA
Suwit Saekho
Department of Radiological Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai Province, Thailand

Abstract

Background: Methamphetamine (MA) is a highly addictive stimulant causes neurotoxicity. Changes of brain metabolites and brain volumes in MA abusers have been documented. However, the relationship between changes of brain metabolites at a selected brain location and changes of brain volumes at the same location has never been reported.


Objectives: To explore the relationship between brain metabolites and brain volumes from the same locations in MA users.


Materials and methods: Ten MA users and 14 Healthy control (HC). For the brain volumes, T1-weighted high resolution images were acquired using 3D FFE pulse sequence. FreeSurfer version 5.3 was applied for brain volumes analysis. Single voxel MRS was acquired in 4 voxel locations and using PRESS pulse sequence for scanning. TARQUIN version 4.3.5 was applied for brain metabolites. Pearson correlations was used to analyze the correlation between brain metabolites and brain volumes in MA users.


Results: MA users showed significantly reduced NAA (p=0.023) and NAA/Cho (p=0.05) in left FWM, compared with HC group. In left BG region, MA user group showed significantly reduced NAA/Cho (p=0.042) and increased Cho (p=0.05), compared with HC group. MA user group showed significantly reduced FGM volume (p=0.043). For the analysis of relationship between metabolites and brain volume, it was found that there are significant correlations between reducing of NAA at FGM region and FGM volume (n=10, r=0.635, p=0.049), and significant negative correlations between reducing of Cr at PGM region and OGM volume (n=10, r= -0.741, p=0.022).


Conclusion: Significant correlations between brain metabolites and brain volumes at FGM and PGM regions.

Article Details

How to Cite
Intachai, N., Rodkong, A., Sailasuta, N., Aramrattana, A., Uttawichai, K., Thompson, M., Sirirojn, B., Thavornprasit, D., Taejaroenkul, S., sintupat, K., Valcour, V., Paul, R., & Saekho, S. (2017). The relationship between metabolite from 1H-MRS and brain volume by magnetic resonance technique in methamphetamine users. Journal of Associated Medical Sciences, 50(3), 424. Retrieved from https://he01.tci-thaijo.org/index.php/bulletinAMS/article/view/84652
Issue
Vol. 50 No. 3 (2017): September-December
Section
Research Articles

Personal views expressed by the contributors in their articles are not necessarily those of the Journal of Associated Medical Sciences, Faculty of Associated Medical Sciences, Chiang Mai University.

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