Acetylcholinesterase and butyrylcholinesterase levels of healthy volunteers who not exposed to pesticides in Chiang Mai Province

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Published: May 2, 2017
Keywords:
Acetylcholinesterase butyrylcholinesterase human red blood cell serum

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Supawatchara Singhatong
Division of Clinical Chemistry, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai Province, Thailand

Abstract

Background: Food contamination of pesticides, especially organophosphate and carbamate, leads to changes in cholinesterase level. Thus, using of previous reference value of enzymes to predict the severity of pesticides exposure may be misleading.


Objectives: To evaluate the recent reference intervals of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) of healthy volunteers who did not expose to pesticides in Chiang Mai Province.


Materials and methods: Three hundred and forty blood samples were collected from healthy volunteers attended in blood donation at Nakornping Hospital, Chiang Mai. The participants did not exposure to pesticides. Level of red blood cell AChE and serum BChE were determined based on spectrophotometric assay. Reference interval was calculated and presented as arithmetic mean±SD.


Results: Levels of red blood cell AChE and serum BChE from male healthy volunteers were not statistically different from those of female. Reference interval of red blood cell AChE and serum BChE are 5,136±1,452 U/L (3,684-6,588 U/L) and 3,164±1,264 U/L (1,900-4,428 U/L), respectively. 


Conclusion: From this study, reference interval of red blood cell AChE and serum BChE can be used for diagnosis of organophosphate and carbamate intoxication in forensic laboratory.


Journal of Associated Medical Sciences 2017; 50(2): 168-175. Doi: 10.14456/jams.2017.16

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How to Cite
Singhatong, S. (2017). Acetylcholinesterase and butyrylcholinesterase levels of healthy volunteers who not exposed to pesticides in Chiang Mai Province. Journal of Associated Medical Sciences, 50(2), 168. Retrieved from https://he01.tci-thaijo.org/index.php/bulletinAMS/article/view/79685
Issue
Vol. 50 No. 2 (2017): May-August
Section
Research Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Personal views expressed by the contributors in their articles are not necessarily those of the Journal of Associated Medical Sciences, Faculty of Associated Medical Sciences, Chiang Mai University.

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