The case report: Effect of red blood cell transfusion on hemoglobin (Hb) analysis of β0-Thalassemia/HbE disease and homozygous HbE

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Published: Jan 1, 2017
Keywords:
Blood transfusion β0-thalassemia HbE misinterpretation

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Sakorn Pornprasert
Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand

Abstract

       Red blood cell (RBC) transfusion is a medical therapy in patients with severe thalassemia and he­moglobinopathy. However, it also affects the hemoglobin (Hb) analysis. We report here the presentation of HbA peak on capillary electrophoresis (CE) electrophoregrams of β0-thalassemia/HbE and homozygous HbE patients who received RBC transfusions. The misinterpretations of β+-thalassemia/HbE and heterozygous HbE, respectively, were occurred. Therefore, to avoid misdiagnosis, hemoglobin analysis should be determined prior to or after 3 months of blood transfusion. When hemoglobin typing is needed within the 3 month period mentioned, history of transfusion is required to accompany the diagnosis. Moreover, molecular analysis for identification of thalassemia genotype should be performed.


Journal of Associated Medical Sciences 2017; 50(1): 22-26. Doi: 10.14456/jams.2017.2

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How to Cite
Pornprasert, S. (2017). The case report: Effect of red blood cell transfusion on hemoglobin (Hb) analysis of β0-Thalassemia/HbE disease and homozygous HbE. Journal of Associated Medical Sciences, 50(1), 22. Retrieved from https://he01.tci-thaijo.org/index.php/bulletinAMS/article/view/73562
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Vol. 50 No. 1 (2017): January-April
Section
Research Articles
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Personal views expressed by the contributors in their articles are not necessarily those of the Journal of Associated Medical Sciences, Faculty of Associated Medical Sciences, Chiang Mai University.

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