Screening and identication of alloantibodies in blood samples from Community Medical Service Project, Faculty of Associated Medical Sciences, Chiang Mai University

Abstract

Individuals with history of blood transfusion, transplantation or pregnancy might develop alloantibodies specific to red blood cell antigens. This work aimed to screen and identify alloantibodies in blood samples from the Community Medical Service Project, Faculty of Associated Medical Sciences, Chiang Mai University. Antibody detection was performed in 1,048 blood samples from 5 community sites during April-December 2011. The result showed that distribution of blood group O, B, A, and AB were 459 (43.8%), 306 (29.2%), 228 (21.8%), and 55 (5.2%), respectively. Four individuals were Rh negative (0.38%). There were 41 blood samples (3.9%) showed positive with antibody screening but only 13 cases (3 male and 10 female, 31.7%) were identified according to small volume of blood sample. Identified alloantibodies included anti-Mia (8 samples, 61.5%), anti-P1 (2 samples, 15.4%), anti-M (2 samples, 15.4%), and anti-D (1 sample, 7.7%). The additional data, including history of blood transfusion and/or pregnancy were reviewed. History of blood transfusion and/or pregnancy in women was reviewed and it was corresponded to those alloantibodies reported. One sample of anti-M was detected from male subject who showed no history of blood transfusion. Results from this finding provide enefit for preparing of appropriate blood components for those with alloantibodies in order to reduce risk of blood transfusion reaction.