Lineage assignment role of immunophenotyping in acute leukemia

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Published: May 2, 2012
Keywords:
immunophenotyping lineage assignment acute leukemia multiparameter flow cytometry

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Nopporn Juengpichanvanich
1 Department of Clinical Pathology, Nakornping Hospital, Chiang Mai, Thailand 2 Division of Clinical Pathology, Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand 3 Hematology Division, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Charin Ya-in
1 Department of Clinical Pathology, Nakornping Hospital, Chiang Mai, Thailand 2 Division of Clinical Pathology, Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand 3 Hematology Division, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Lertlakana Bhoopat
1 Department of Clinical Pathology, Nakornping Hospital, Chiang Mai, Thailand 2 Division of Clinical Pathology, Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand 3 Hematology Division, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Lalita Norasetthada
1 Department of Clinical Pathology, Nakornping Hospital, Chiang Mai, Thailand 2 Division of Clinical Pathology, Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand 3 Hematology Division, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

Abstract

Objective:


To assess the role of routine multiparameter flow cytometry, for lineage assignment of leukemic cells in patients with acute leukemia.


Materials and Methods:


One hundred cases of adult and children patients diagnosed with acute leukemia admitted at Maharaj Nakorn Chiang Mai Hospital during 2010 were reviewed. Bone marrow samples were immunophenotyped by multiparameter flow cytometry compared to morphology.


Results:


In our retrospective analysis of 100 cases, morphology established lineage in all cases (100%). However, immunophenotyping significantly indicated lineage assignment difference from morphology in 16 cases (16%) with p<0.001. The first group of 8 cases was reported to be lymphoid from previously reported myeloid. The second group of 8 cases was confirmed to be myeloid from previously reported lymphoid.


Conclusion:


The results addressed the significant benefit and supported routine application of immunophenotyping in the diagnosis of acute leukemia.

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How to Cite
Juengpichanvanich, N., Ya-in, C., Bhoopat, L., & Norasetthada, L. (2012). Lineage assignment role of immunophenotyping in acute leukemia. Journal of Associated Medical Sciences, 45(2), 9. Retrieved from https://he01.tci-thaijo.org/index.php/bulletinAMS/article/view/60032
Issue
Vol. 45 No. 2 (2012): May-August
Section
Research Articles

Personal views expressed by the contributors in their articles are not necessarily those of the Journal of Associated Medical Sciences, Faculty of Associated Medical Sciences, Chiang Mai University.