Evaluation of estimated glomerular filtration rate (eGFR) by reference range of serum creatinine at Buddhachinaraj Phitsanuloke Hospital

Abstract

       The Nephrology Society of Thailand has recommended to report routine serum creatinine (Cr) testing along with the estimated glomerular filtration rate (eGFR). This study was to compare eGFR between two equations, the reexpressed Modification of Diet in Renal Disease study (MDRD) and the CKD-EPI. Six hundred and seventy seven healthy subjects were enrolled in this study. The data of serum Cr, age, gender, and ethnic of study subjects were used to calculate eGFR. The serum Cr was measured by using the modified Jaffe compensation. The reference range of serum Cr was established by using the National Committee for Clinical Laboratory Standard (NCCLS document C28-A2) guideline. The eGFR obtained from the reexpressed MDRD equation was 69-131 mL/min/1.73 m2 in female and 68-115 mL/min/1.73 m2 inmale while the eGFR obtained from the CKD-EPI equation was 72-119 mL/min/1.73 m2 in female and 70-112 mL/min/1.73 m2 in male. There was significantly different (p<0.001) of eGFRs obtained from two equations and especially, when eGFR > 60 mL/min/1.73 m2. The reference range of serum Cr was 0.44-1.04 mg/dL in female and 0.75- 1.25 mg/dL in male.  Bull Chiang Mai Assoc Med Sci 2013; 46(3): 260-272