Relationship of platelet glycoprotein Ia C807T/G873A gene polymorphisms to severity of coronary artery stenosis in Thai patients with coronary artery disease

Abstract

Individuals who have more numbers of healed plaque rupture and hypercoagulable state such as high platelet activity may have an impact on a rapid progression of vascular stenosis. The C807T/ G873A polymorphisms in the glycoprotein (GP) Ia gene are associated with a variable expression of the receptor on platelet membrane which involved in platelet adhesion to the injured vessel. This study therefore aimed to determine the relationship between platelet GPIa C807T/G873A gene polymorphisms and the severity of vascular stenosis in Thai patients. A total of 212 subjects who clinically suspected for coronary artery disease (CAD) underwent coronary angiography at the Cardiac Catheterization Unit, Queen Sirikit Heart Center of the Northeast Hospital, Khon Kaen University were recruited in the study. The polymorphisms were determined by multiplex allele specific polymerase chain reaction whilst the severity of CAD was evaluated by Gensini scoring system and the number of major coronary artery with stenosis greater than 50%. The results showed that genotype frequencies of CC/GG, CT/GA and TT/AA were 56.6, 37.3 and 6.1%, respectively. In addition, association of the polymorphisms with the severity of CAD evaluated by using either Gensini score or the number of vascular stenosis was not demonstrated. In conclusion, the results of this study suggest that determination of GPIa C807T/G873A polymorphisms may not be enough for prediction of the severity of vascular stenosis in Thai patients with CAD. Bull Chiang Mai Assoc Med Sci 2013; 46(3): 273-284