Brief review: Effects of textural properties of lamellar silica in drug delivery applications
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Abstract
Background: Silica-based materials, especially those with lamellar morphology, usually have other names, such as dendritic, nanoflower, and wrinkle are often used in various applications due to their unique textural properties, such as radially centered pore structure, pore channels, and large pore volume.
Objectives: To determine the effect of lamellar silica texture properties, such as surface area, porosity, pore size, morphological shape, particle size, and surface charge value, as potential drug delivery material candidates. Materials and methods: The texture properties of silica materials were reviewed in drug delivery applications, and four silica materials with different morphologies were reviewed for their texture properties and potential in drug delivery applications.
Results: The literature review revealed the effect of material texture properties on their potential in drug delivery applications. Drug loading in porous carriers can improve their activity, stability, and selectivity, and can reduce the drug dose to inhibit cell viability compared to unencapsulated drugs. Surface modification can also affect the zeta potential value and its performance in drug loading. In vitro drug release properties of the material and drug release rates showed different results related to their different texture properties. Particle size affects particle penetration into cells; the smaller the particle size, will cause deeper the penetration, but it has a tendency for particle aggregation.
Conclusion: Lamellar silica-based materials with various unique properties of their texture properties show great potential in drug delivery applications and are expected to be used in the future.
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Personal views expressed by the contributors in their articles are not necessarily those of the Journal of Associated Medical Sciences, Faculty of Associated Medical Sciences, Chiang Mai University.
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