Review article: Local medicinal plants in Nigeria for the management of diabetes; an evaluating of glucose metabolism, insulin sensitivity, and physiological parameters
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Abstract
Background: Nigeria, like many regions worldwide, faces a growing burden of diabetes, prompting increased interest in traditional medicinal practices.
Objective: This review examines the efficacy of local medicinal plants in Nigeria for managing diabetes mellitus, focusing on their effects on glucose metabolism, insulin sensitivity, and physiological parameters.
Materials and methods: Four commonly used plants, Aloe vera, bitter leaf (Vernonia amygdalina), bitter lemon (Citrus aurantium), and ginger (Zingiber officinale), were scrutinized for their potential therapeutic effects.
Results: The literature review revealed numerous studies exploring the antidiabetic properties of these plants, including their ability to lower blood glucose levels, improve insulin sensitivity, and modulate various physiological parameters associated with diabetes.
Conclusion: The findings suggest promising avenues for utilizing local medicinal plants in diabetes management, although further research, including clinical trials, is warranted to validate their efficacy and safety.
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Personal views expressed by the contributors in their articles are not necessarily those of the Journal of Associated Medical Sciences, Faculty of Associated Medical Sciences, Chiang Mai University.
References
Evert AB, Dennison M, Gardner CD, Garvey WT, Lau KHK, MacLeod J, and Yancy WS. Nutrition therapy for adults with diabetes or prediabetes: A consensus report. Diabetes Care. 2019; 42(5): 731-54. doi: 10.2337/ dci19-0014.
Gupta RK, Patel AK, Shah N, Chaudhary AK, and Jha UK. A review on medicinal plants with antidiabetic activity. J Pharmacogn Phytochem. 2017; 6(6): 2340-5. doi:10.7897/2230-8407.097122
Hu FB, Manson JE, Stampfer MJ, Colditz G, Liu S, Solomon CG, et al. Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. New England J Med. 2011; 345(11): 790-7. doi: 10.1056/NEJMoa010492.
Piko P, Werissa NA, Fiatal S, Sandor J, and Adany R. Impact of Genetic Factors on the Age of Onset for Type 2 Diabetes Mellitus in Addition to the Conventional Risk Factors. J Pers Med. 2020; 11(1): 6. doi: 10.3390/jpm11010006.
Kahn SE, Hull RL, and Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006; 444(7121): 840-6. doi: 10.1038/nature 05482.
Malik VS, Popkin BM, Bray GA, Després JP, and Willett WC. Sugar-sweetened beverages, obesity, type 2 diabetes mellitus, and cardiovascular disease risk. Circulation. 2010; 121(11): 1356-64. doi: 10.1161/ CIRCULATIONAHA.109.876185.
Colberg SR, Sigal RJ, Yardley JE, Riddell MC, Dunstan DW, Dempsey PC, et al. Physical activity/exercise and diabetes: A position statement of the American Diabetes Association. Diabetes Care. 2016; 39(11): 2065-79. doi.org/10.2337/dc16-1728
Vincent AM, Russell JW, Sullivan KA, Backus C, Hayes JM, McLean LL, et al. SOD2 protects neurons from injury in cell culture and animal models of diabetic neuropathy. Exp Neurol. 2004; 186(2): 216-27
Aloke C, Egwu CO, Aja PM, Obasi NA, Chukwu J, Akumadu BO, et al. Current advances in the management of diabetes mellitus. Biomedicines. 2022; 10(10): 2436. doi.org/10.3390/biomedicines10102436
Grover JK, Yadav S. Pharmacological actions and potential uses of Momordica charantia: A review. J Ethnopharmaco. 2004; 93(1): 123-32. doi: 10.1016/j. jep.2004.03.035.
Surjushe A, Vasani R, and Saple DG. Aloe vera: A short review. Indian J Dermatol. 2008; 53(4): 163-6. doi: 10.4103/0019-5154.44785.
Sánchez M, González-Burgos E, Iglesias I, and Gómez- Serranillos MP. Pharmacological update properties of aloe vera and its major active constituents. Molecules (Basel, Switzerland). 2020; 25(6): 1324. doi: 10.3390/ molecules25061324.
Paulsen E. Aloe vera gel research review. J Nat Med. 2009; 1(1): 1-5.
Hekmatpou D, Mehrabi F, Rahzani K, and Aminiyan A. The Effect of Aloe Vera Clinical Trials on Prevention and Healing of Skin Wound: A Systematic review. Iran J Med Sci. 2019; 44(1): 1-9. PMCID: PMC63305 25.PMID: 30666070
Syed TA, Ahmad SA, Holt AH, Ahmad SA, Ahmad SH, and Afzal M. Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo-controlled, double-blind study. Trop Med Int Health. 1996; 1(4): 505-9. doi: 10.1046/j.1365-3156.1996.d01-91.x.
Langmead L, Feakins RM, Goldthorpe S, Holt H, Tsironi E, De Silva A, et al. Randomized, double-blind, placebo- controlled trial of oral aloe vera gel for active ulcerative colitis. Aliment Pharmacol Ther. 2004; 19(7): 739-47. doi: 10.1111/j.1365-2036.2004.01902.x.
Davis K, Philpott S, Kumar D, and Mendall M. Randomised double-blind placebo-controlled trial of aloe vera for irritable bowel syndrome. Int J Clin Pract.2006; 60(9): 1080-6. doi: 10.1111/j.1742- 1241.2006.00980.x.
Vogler BK, and Ernst E. Aloe vera: A systematic review of its clinical effectiveness. Br J Gen Prac. 1999; 49(447): 823-8. PMID: 10885091, PMCID: PMC1313538
Yagi A, Kabash A, Okamura N, Haraguchi H, Moustafa SM, Khalifa TI. Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera. Planta Medica. 2002; 68(11): 957-60. https://doi.org/10.1055/S-2002-35666/ID/2
Dede S, Isirima J, and Akoko S. Antihyperglycemic and histological effect of Aloe vera on alloxan-induced diabetes in Wistar rats. Scholars Int J Integr Med. 2023; 6: 120-8. doi.org/10.36348/sijtcm.2023.v06i08.001
Arora M, Sarup Y, Tomar R, Singh M, and Kumar P. Amelioration of diabetes-induced diabetic nephropathy by Aloe vera: Implication of oxidative stress and hyperlipidemia. J Diet. 2018; Suppl16(1): 1-18. https://doi.org/10.1080/19390211.2018.1499474
Boudreau MD, Beland FA, and Nichols JA. Toxicology and carcinogenesis studies of a nondecolorized whole leaf extract of Aloe barbadensis Miller (Aloe vera) in F344/N rats and B6C3F1 mice (drinking water study). Natl Toxicol Program Tech Rep Ser. 2013; 577: 1-266. PMID: 24042237
Ghosh S, and Das S. Quercetin selectively inhibits insulin receptor function in vitro by impairing insulin binding. Br J Pharmacol. 2010; 161(2): 424-40. doi: 10.1021/bi00149a041.
Mosisa Gudeta, B., Melesie Taye, G., Abula, T., & Alemayehu Gadisa, D. Evaluation of anti-diarrheal activity of 80% methanol extracts of vernonia amygdalina delile (asteraceae) leaves in mice. Journal of Experimental Pharmacology. 2020; 455-462.
Boudreau MD, Beland FA, and Nichols JA. Toxicology and carcinogenesis studies of a nondecolorized whole leaf extract of Aloe barbadensis Miller (Aloe vera) in F344/N rats and B6C3F1 mice (drinking water study). Natl Toxicol Progr Tech Rep Ser. 2013; 577: 1-266. PMID: 24042237.
Farombi O, and Owoeye O. Antioxidative and Chemopreventive Properties of Vernonia amygdalina and Garcinia biflavonoid. Int J Environ Res Public Health. 2011; 8: 2533-55. doi: 10.3390/ijerph8062533.
Igoli J, Ogaji O, Tor-Anyiin T. and Igoli N. Traditional medicine practice amongst the Igede people of Nigeria. Part II. Afr J Trad CAM. 2005; 2(2): 134-52. doi:10.4314/ajtcam.v2i2.31112
Omoregie ES, and Pal A. Antiplasmodial, antioxidant and immunomodulatory activities of ethanol extract of Vernonia amygdalina del. Leaf in Swiss mice. Avicenna J Phytomed. 2016; 6(2): 236-47. PMID: 272 22837, PMCID: PMC4877969
Akerele GP, Adedayo C, Oboh, G, Ademosu AO, and Oyeleye SI. Glycemic indices and effect of bitter leaf (Vernonia amygdalina) flavored non-alcoholic wheat beer (NAWB) on key carbohydrate metabolizing enzymes in high fat diet fed (HFD)/STZ-induced diabetic Wistar rats. J Food Biochem. 2022; 46(12): e14511. 4. doi: 10.1111/jfbc.14511.
Atangwho IJ, Yin KB, Umar MI, Ahmad M, and Asmawi MZ. Vernonia amygdalina simultaneously suppresses gluconeogenesis and potentiates glucose oxidation via the pentose phosphate pathway in streptozotocininduced diabetic rats. BMC Complementary Altern Med. 2014; 14: 426. doi: 10.1186/1472-6882-14-426.
Adedapo AA, Aremu OJ, and Oyagbemi AA. Antioxidant, anti-inflammatory and antinociceptive properties of the acetone leaf extract of vernonia amygdalina in some laboratory animals. Adv Pharm Bull. 2014; 4(Suppl 2): 591-8. doi: 10.56 81/apb.2014. 087.
Aruoma OI, Colognato R, Fontana I, Gartlon J, Migliore L, and Koike K. Molecular effects of fermented papaya preparation on oxidative damage, MAP Kinase activation and modulation of the benzo[a] pyrene mediated genotoxicity. Biofactors. 2000; 12(1-4): 229-40. doi: 10.1002/biof.5520260205.
Jaiswal N, Pardhasaradhi PV, and Kuhnert N. Phenolic compounds from Vernonia amygdalina and their antioxidant activities. Ind Crop Prod. 2017; 95: 662-7.
Johnbull O, Igbe I, Obsrisiagbon P, and Onyegbula C. Studies on the effects of Vernonia amygdalina aqueous leaf extract on the biochemical, hematological, and hypoglycemic parameters in diabetic rats: Prerequisite to formulation into pharmaceutical dosage form. J med Pharm Allied Sci. 2019; 16.
Nwaoguikpe R. The effect of extract of bitter leaf (Vernonia amygdalina) on blood glucose levels of diabetic rats. Int J Biol Chem Sci. 2010; 4(3): 788-96. doi.org/10.4314/ijbcs.v4i3.60500
Oboh G, Ademiluyi AO, and Akinyemi AJ. Inhibition of α-amylase and α-glucosidase activities by ethanolic extract of Vernonia amygdalina leaf: an in vitro assessment. J Taibah Univ Sci. 2016; 10(5): 600-6. doi: 10.1016/S2221-1691(12)60219-6.
Kim B, Lee HS, Kim HJ, Lee H, Lee IY, Ock S, Kwon S, Kang SS, Choi Y. Momordica charantia (bitter melon) efficacy and safety on glucose metabolism in Korean prediabetes participants: a 12-week, randomized clinical study. Food Sci Biotechnol. 2022; 14;32(5):697-704. doi: 10.1007/s10068-022-01214-9. PMID: 37009042; PMCID: PMC10050654.
Duke JA. Duke’s handbook of medicinal plants of Latin America. CRC Press.2008
Mohammady I, Elattar S, Mohamed S, and Ewais M. An evaluation of anti-diabetic and anti-lipidemic properties of Momordica charantia (bitter melon) fruit extract in experimentally induced diabetes. J Life Sci. 2012; 9(4): 363-74.
Jia S, Shen M, Zhang F, Xie J. Recent Advances in Momordica charantia: Functional Components and Biological Activities. Int J Mol Sci. 2017; 18(12):2555. doi: 10.3390/ijms18122555. PMID: 29182587; PMCID: PMC5751158.
Joseph B, and Jini D. Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency. Asian Pac J Trop Dis. 2013; 3(2): 93-102. doi: 10.1016/ S2222-1808(13)60052-3
Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, and Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipid. 2015; Article 496169. doi.org/10.1155/2015/496169.
Mahwish FS, Nosheen F, Qurat-ul-Ain NB, Afzaal M, Ehsan K, Hussain M, Imran M, and Al JE. Bioevaluation of alkaloids and saponins from bitter melon: Probing more desirable compounds in treating hyperglycemia and hyperlipidemia. Cogent Food Agri. 2023; 9(1): 1-16. doi:10.1080/23311932.2023. 2242634
Yadav M, Jain S, Tomar R, Prasad GB, and Yadav H. Medicinal and biological potential of pumpkin: an updated review. Nutr Res Rev. 2010; 23(2): 184-90. doi: 10.1017/S0954422410000107.
Grover JK, Yadav SP, and Vats V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol. 2002; 81(1): 81-100. doi: 10.1016/s0378-8741(02)00 059-4.
Bhattacharya S, Muhammad N, Steele R, Kornbluth J, and Ray RB. Bitter Melon Enhances Natural KillerMediated Toxicity against Head and Neck Cancer Cells. Cancer Prev Res (Philadelphia, Pa.). 2017; 10(6): 337-44. doi: 10.1158/1940-6207.CAPR-17-0046
Sur S, and Ray RB. Diverse roles of bitter melon (Momordica charantia) in prevention of oral cancer. J Cancer Metastasis Treat. 2021; 7: 12. https://doi. org/10.20517/2394-4722.2020.124
Leatherdale BA, Panesar RK, Singh G, and Atkins TW. Improvement in glucose tolerance due to Momordica charantia (karela). Br Med J (Clin Res Ed). 1981; 282(6279): 1823-4. doi: 10.1136/bmj.282.6279.1823.
Ahmed I, Adeghate E, Cumming E, and Sharma AK. Beneficial effects and mechanisms of action of Momordica charantia juice in the treatment of streptozotocin-induced diabetes mellitus in rat. Mol Cell Biochem. 2012; 368(1-2): 59-73. doi: 10.1023/ b:mcbi.0000028738.95518.90.
Basch E, Gabardi S, and Ulbricht C. Bitter melon (Momordica charantia): A review of efficacy and safety. Am J Health Syst Pharm. 2003; 60(4): 356-9. doi: 10.1093/ajhp/60.4.356.
Fuangchan A, Sonthisombat P, Seubnukarn T, Chanouan R, Chotchaisuwat P, and Sirigulsatien V. Hypoglycemic effect of bitter melon compared with metformin in newly diagnosed type 2 diabetes patients. J Ethnopharmacol. 2011; 134(2): 422-8. doi: 10.1016/j.jep.2010.12.045.
Oishi Y, Sakamoto T, Udagawa H, Taniguchi H, and Kobayashi-Hattori K. Momordica charantia L. improves insulin resistance and disordered lipid metabolism in a high-fructose diet-induced NAFLD mouse model. Arch Biochem Biophys. 2019; 662: 169-78. doi: 10.3389/fphar.2021.770652
Ooi CP, Yassin Z, Hamid TA, & Momtaz YA. Momordica charantia for type 2 diabetes mellitus. Cochrane Database Sys Rev. 2013; (8): CD007845. https://doi. org/10.1002/14651858.CD007845.pub3
Grzanna, R., Lindmark, L., & Frondoza, C. G. Ginger-- an herbal medicinal product with broad antiinflammatory actions. Journal of medicinal food. 2005; 8(2), 125–132. https://doi.org/10.1089/jmf. 2005.8.125
Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, and Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipid. 2015; Article 496169. https://doi.org/10.1155/2015/496169.
Ali BH, Blunden G, Tanira MO, and Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research. Food Chem Toxicol. 2008; 46(2): 409–20. doi: 10.1016/j.fct.2007.09.085.
Black CD, Herring MP, Hurley DJ, and O’Connor PJ. Ginger (Zingiber officinale) reduces muscle pain caused by eccentric exercise. J Pain. 2010; 11(9): 894-903. doi: 10.1016/j.jpain.2009.12.013.
Ernst E, and Pittler MH. Efficacy of ginger for nausea and vomiting: A systematic review of randomized clinical trials. Br J Anaesth. 2000; 84(3): 367-71. doi: 10.1093/oxfordjournals.bja.a013442.
Viljoen E, Visser J, Koen N, and Musekiwa A. A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancyassociated nausea and vomiting. Nutr J. 2014; 13: Article 20. doi.org/10.1186/1475-2891-13-20
Islam MS, and Choi H. Comparative effects of dietary ginger (Zingiber officinale) and garlic (Allium sativum) investigated in a type 2 diabetes model of rats. J Med Food. 2008; 11(1): 152-9. doi.org/10.1089/jmf. 2007.601.3r
Grzanna, R., Lindmark, L., & Frondoza, C. G. Ginger an herbal medicinal product with broad antiinflammatory actions. Journal of medicinal food. 2005; 8(2), 125–132. https://doi.org/10.1089/jmf.2005. 8.125
Rahmani AH, Shabrmi FM, and Aly, SM. Active ingredients of ginger as potential candidates in the prevention and treatment of diseases via modulation of biological activities. Int J Physiol Pathophysiol Pharmacol. 2014; 6(2): 125-36. PMCID: PMC4106 649 PMID: 25057339
Mao QQ, Xu XY, Cao SY, Gan RY, Corke H, Beta T, and Li HB. Bioactive compounds and bioactivities of ginger (Zingiber officinale Roscoe). Foods (Basel, Switzerland). 2019; 8(6): 185. doi: 10.3390/foods8060185.
Mashhadi NS, Ghiasvand R, Askari G, Hariri M, Darvishi L, and Mofid MR. Anti-oxidative and antiinflammatory effects of ginger in health and physical activity: Review of current evidence. Int J Prev Med. 2013; 4(Suppl 1): S36-S42. PMID: 23717767, PMCID: PMC3665023
Bode AM, and Dong Z. The amazing and mighty ginger. In Herbal Medicine: Biomolecular and Clinical Aspects (2nd ed.). Boca Raton (FL): CRC Press/Taylor & Francis.2011
Kundu JK, Na HK, and Surh YJ. Ginger-derived phenolic substances with cancer preventive and therapeutic potential. Forum of Nutr. 2009; 61: 182-92. doi: 10.1159/ 000212750.
Gan FF, Nagle AA, and Ang X. Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. J Cardiovasc Pharmacol. 2011; 57(4): 468-73. doi: 10.1097/00005344-200501000- 00013
Akhani SP, Vishwakarma SL, Goyal RK, and Chauhan DK. Pharmacological evaluation of Cucumis sativus Linn. for central nervous system depressant activity. J Basic Clin Physiol Pharmacol. 2014; 25(3): 335-42. doi:10.3126/jucms.v11i03.61478
Arablou T, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A, and Djalali M. The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus. Int J Food Sci Nutr. 2014; 65(4): 515-20. doi: 10.3109/09637486.2014.880671
Daily JW, Zhang X, Kim DS, and Park S. Efficacy of ginger for treating type 2 diabetes: A systematic review and meta-analysis of randomized clinical trials. J Ethn Foods. 2015; 2(1): 36-43. doi:10.1016/j. jef.2015.02.007
Al-Azhary D. Ginger enhances antioxidant activity and attenuates atherogenesis in diabetic cholesterolfed rats. Aust J Basic Appl Sci. 2010; 5(10): 1357-64.
American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2021; 44(Supplement_1): S15-S33.
Ojewole JA. Analgesic, anti-inflammatory, and hypoglycemic effects of ethanol extract of Zingiber officinale (Roscoe) rhizomes (Zingiberaceae) in mice and rats. Phytother Res: PTR. 2006; 20(9): 764-72. doi.org/10.1002/ptr.1924
Langner E, Greifenberg S, and Gruenwald J. Ginger: history and use. Adv Ther. 1998; 15(1): 25-44. PMID: 10178636.
Mozaffari-Khosravi H, Talaei B, Jalali BA, Najarzadeh A, and Mozayan MR. The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial. Complement Ther Med. 2014; 22(1): 9-16. doi: 10.1016/j.ctim.2013. 12.017.
White B. Ginger: An overview. Am Fam Physician. 2007; 75(11): 1689-91. PMID: 17575660
Dumanoglu B, Alpagat G, Poyraz M, Alan YS, and Baccioglu A. Anaphylaxis After Consumption of Guar Gum-Containing Food: A Report of Two Cases. Cureus. 2022; 14(8): e28022. doi: 10.7759/cureus. 28022
Khandouzi N, Shidfar F, Rajab A, Rahideh T, Hosseini P, and Mir Taheri M. The effects of ginger on fasting blood sugar, hemoglobin a1c, apolipoprotein B, apolipoprotein a-I and malondialdehyde in type 2 diabetic patients. Iran J Pharm Res: IJPR. 2015; 14(1): 131-40. PMID: 25561919, PMCID: PMC4277626
Chuah SK, Wu KL, Tai WC, and Changchien CS. The effects of ginger on gallbladder motility in healthy male humans. J Neurogastroenterol Motil. 2011; 17(4): 411-5. doi: 10.5056/jnm.2011.17.4.411.