The measurement of radiation doses in brachytherapy using an alanine dosimeter
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Abstract
Background: Brachytherapy involves the use of high radiation doses to treat cancer patients, making it essential to have appropriate dosimeter properties to confirm the accuracy and precision of the dose delivered to the patient.
Objectives: This study was to investigate the relationship between radiation dose and electron spin resonance (ESR) signal and to evaluate the optimal conditions for the ESR technique. Additionally, the radiation dose from brachytherapy was measured in a solid phantom using alanine in combination with the ESR technique.
Materials and methods: The alanine dosimeter (FWT-50-10, Steris, USA), ionization chamber (TW30013, PTW Freiburge, Germany), and transferring tube were positioned inside the solid phantom (Krieger, T9193, PTW Freiburge, Germany), with the BEBIG Co-60 source located at the center of the phantom. Dwell times were calculated to obtain a radiation dose range of 0.06-1.5 Gy. Following irradiation, the alanine derivative was measured using an ESR spectrometer, and a graph was generated to determine the relationship between radiation dose and ESR signal. The uncertainty and fading of the ESR signal were also evaluated.
Results: The results indicate that there is a linear relationship (R2 = 0.877) between the radiation dose range of 0.49-1.5 Gy and ESR signal, with a microwave power of 1.5 milliwatt. The uncertainty of the ESR signal was found to be in the range of 0.12% - 3.79%. Signal fading was observed to be in the range of 7.2% - 27.4% over a period of two weeks.
Conclusion: Alanine and ESR technique can be used to measure absorbed dose in brachytherapy. The dose response of alanine was linear for radiation doses above 0.49 Gy. The advantages of alanine dosimetry are that alanine is tissue equivalent, nondestructive, small in size, and has low signal uncertainty.
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References
ICRU REPORT 93: Prescribing, Recording, and Reporting Light Ion Beam Therapy. 4. Dosimetry. Journal of the ICRU. 2016; 16(1-2): 59-70. doi: 10.1093/jicru_ndy021.
World Health Organization & Institut für Strahlenhygiene des Bundesgesundheitsamtes (Germany), Federal Republic of. (1988). Quality assurance in radiotherapy: a guide prepared following a workshop held at Schloss Reisensburg, Federal Republic of Germany, 3-7 December 1984 / organized jointly by Institute of Radiation Hygiene, Federal Health Office, Neuherberg, Federal Republic of Germany and World Health Organization, Geneva, Switzerland. World Health Organization. https://apps.who.int/iris/handle/10665/40423.
Alves GG, Kinoshita A, Oliveira HF, Guimarães FS, Amaral LL, Baffa O. Accuracy of dose planning for prostate radiotherapy in the presence of metallic implants evaluated by electron spin resonance dosimetry. Braz J Med Biol Res. 2015; 48(7): 644-9. doi: 10.1590/1414-431X20154367.
Baffa O, Kinoshita A. Clinical applications of alanine/electron spin resonance dosimetry. Radiat Environ Biophys. 2014; 53(2): 233-40. doi: 10.1007/s00411-013-0509-2.
Garcia T, Lin M, Pasquie I, Lourenço V. A methodology for choosing parameters for ESR readout of alanine dosimeters for radiotherapy. Radiat Phys Chem. 2009; 78: 782-90. doi: 10.1016/j.radphyschem.2009.05.020.
Intang A, Oonsiri P, Kingkaew S, Chatchumnan N, Tangboonduangjit P, Stansook N, et al. Investigation of alanine dosimeter for output measurement in radiotherapy: Results from multicenter in Thailand. J Assoc Med Sci. 2023; 56(2): 106-16. doi: 10.12982/JAMS.2023.039.
Schultka K, Ciesielski B, Serkies K, Sawicki T, Tarnawska Z, Jassem J. EPR/alanine dosimetry in LDR brachytherapy --a feasibility study. Radiat Prot Dosimetry. 2006; 120(1-4): 171-5. doi: 10.1093/rpd/nci528.
Wagner D, Anton M, Vorwerk H, Gsänger T, Christiansen H, Poppe B, et al. In vivo alanine/electron spin resonance (ESR) dosimetry in radiotherapy of prostate cancer: a feasibility study. Radiother Oncol. 2008; 88(1): 140-7. doi: 10.1016/j.radonc.2008.03.017.
Safdar MA. Methods of low dose determination using EPR/alanine radiation dosimetry [Dissertation on the Internet]. [Oslo (Norway)]: University of Oslo; 2019. [cited 2022 Jan 28]. Available from: https://www. duo.uio.no/bitstream/handle/10852/74261/1/ADNAN-THESIS.pdf.
Azhari H, Hensley F, Schütte W, Zakaria G. Dosimetric verification of source strength for HDR afterloading units with Ir-192 and Co-60 photon sources: Comparison of three different international protocols. J Med Phys. 2012; 37(4): 183-92. doi: 10.4103/0971-6203.103603.
Chassagne D, Dutreix A, Almond P, Burgers JMV, Busch M, Joslin CA. 3. Recommendations for reporting absorbed doses and volumes in intracavitary therapy. Reports of the International Commission on Radiation Units and Measurements. 1985; os-20(1): 9-14. doi: 10.1093/jicru_os20.1.9.
Oyekunle EO, Akinlade BI, Uwadiae IB, Ajeleti OG, Adedokun AG. Comparative assessment of radioactive source strengths in two high-dose-rate brachytherapy units using three sets of dosimetry equipment. African J Med Phys. 2019; 2(2): 33-8.
Carlsson TA, Carlsson GA. Influence of phantom material and dimensions on experimental 192Ir source. Med Phys. 2009; 36: 2228-35. doi: 10.1118/1.3121508.
Schaeken B, Cuypers R, Goossens J, Weyngaert D, Verellen D. Experimental determination of the energy response of alanine pellets in the high dose rate 192Ir spectrum. Phys Med Biol. 2011; 56: 6625-34. doi: 10.1088/0031-9155/56/20/007.
Ciesielski B, Schultka K, Kobierska A, Nowak R, Peimel-Stuglik Z. In vivo alanine/EPR dosimetry in daily clinical practice: a feasibility study. Int J Radiat Oncol Biol Phys. 2003; 56(3): 899-905. doi: 10.1016/S0360-3016(03)00196-2.
Gago-Arias A, González-Castaño D, Gómez F, Peteiro E, Lodeiro C, Pardo-Montero J. Development of an alanine dosimetry system for radiation dose measurements in the radiotherapy range. J Instrum. 2015; 10: T08004. doi: 10.1088/1748-0221/10/08/T08004.
Nasreddine A. Alanine/EPR dosimetry for low to medium energy X-ray radiation processing control [Dissertation on the Internet]. [Strasbourg (France)]: Université de Strasbourg; 2020. [cited 2022 Feb 12]. Available from: https://theses.hal.science/tel-03141195/
Helt-Hansen J, Rosendal F, Kofoed IM, Andersen CE. Medical reference dosimetry using EPR measurements of alanine: development of an improved method for clinical dose levels. Acta Oncol. 2009; 48(2): 216-22. doi: 10.1080/02841860802279725.
Gustafsson H. Development of sensitive EPR dosimetry methods. [Dissertation on the Internet]. [Linköping, (Sweden)]: Linköping University; 2008. [cited 2022 Feb 12]. Available from: http://www.diva-portal.org/smash/get/diva2:17549/FULLTEXT01.pdf