Decelerate amyloid fibrillation by the alkaloids extracted from Stephania venosa

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Published: Jun 18, 2023
Keywords:
Amyloid fibrillation alkaloid tyrosine Thioflavin-T

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Krai Daowtak
Department of Medical Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok Province, Thailand.
Wilart Pompimon
Laboratory of Natural Products, Department of Chemistry, Faculty of Science, Lampang Rajabhat University, Lampang Province, Thailand.
Milena Salerno
Université Sorbonne Paris Nord, UMR-CNRS 7244, Laboratoire Chimie, Structures, Propriétés de Biomatériaux et d’Agents Thérapeutiques (CSPBAT), équipe NBD, 1 rue de Chablis, 93000, Bobigny, France
Chatchanok Udomtanakunchai
Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai Province, Thailand.

Abstract

Background: Naturally occurring phytochemical compounds have received considerable attention as alternative candidates for anti-amyloidogenic agents.


Objectives: This study, utilizing human insulin and amyloid-β peptide as an in vitro model, determined the anti-amyloid effects of alkaloids extracted derived from Stephania venosa.


Materials and methods: Alkaloids extracts including crebanine, O-methylbulbocapnine, tetrahydropalmatine and N-methyltetrahydropalmatine were used. The Inhibition of amyloid protein aggregation was studied by fluorescence spectroscopy.


Results: Most alkaloids, except N-methyltetrahydropalmatine, exhibited inhibitory properties against amyloid fibrillation either insulin or amyloid-beta peptide. Among the alkaloids group, crebanine and tetrahydropalmatine showed potent properties of anti-amyloidogenesis.


Conclusion: These results suggest that alkaloids could be used as a natural compound for the development of drugs against amyloid protein aggregation for the treatment of amyloid-related diseases.

Article Details

How to Cite
Daowtak, K., Pompimon, W., Salerno, M., & Udomtanakunchai, C. (2023). Decelerate amyloid fibrillation by the alkaloids extracted from Stephania venosa. Journal of Associated Medical Sciences, 56(3), 52–59. Retrieved from https://he01.tci-thaijo.org/index.php/bulletinAMS/article/view/261067
Issue
Vol. 56 No. 3 (2023): September-December
Section
Research Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Personal views expressed by the contributors in their articles are not necessarily those of the Journal of Associated Medical Sciences, Faculty of Associated Medical Sciences, Chiang Mai University.

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